Relationship between cartilage stiffness and dGEMRIC index: correlation and prediction.

Relationship between cartilage stiffness and dGEMRIC index: correlation and prediction. Research Abstract Details 

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Relationship between cartilage stiffness and dGEMRIC index: correlation and prediction. Abstract Text:

Marta Baldassarri,Jesse S Little Goodwin,Michelle L Farley,Benjamin E Bierbaum,Steven R Goldring,Mary B Goldring,Deborah Burstein,Martha L Gray,

We sought to determine if a generalized relationship between the dGEMRIC index (T1Gd relaxation time) and compressive stiffness of articular cartilage could be defined across multiple samples. Osteochondral blocks were cut from 12 human tibial plateaus, six from cadaveric sources and six from total knee replacement surgeries. Each block contained submeniscal ("covered") and extrameniscal ("uncovered") cartilage regions. At approximately 18 sites per block, a pulse indentation was applied and local dGEMRIC index was determined using dGEMRIC MRI. No correlation was found between stiffness and full cartilage depth dGEMRIC index. When averaged over the depth comparable to the indentation, good correlations were found between stiffness and the dGEMRIC index whether all data were combined, or whether each sample/region was considered independently. However, the standard error of the estimate for predicting stiffness from the local dGEMRIC index was improved when the uncovered and covered regions were considered separately. Further improvement in predictive capacity was obtained if, rather than predict absolute stiffness, differences in the dGEMRIC index across a region were used to predict difference in stiffness. The dGEMRIC index is highly correlated to mechanical stiffness. A generalized relationship was found to provide good correspondence across sources and regions. Use of the dGEMRIC index as a predictive measure of stiffness is possible, depending on the application's acceptable error.

Relationship between cartilage stiffness and dGEMRIC index: correlation and prediction. Publishing Authors By Initials

M Baldassarri,JS Goodwin,ML Farley,BE Bierbaum,SR Goldring,MB Goldring,D Burstein,ML Gray,

For similar musculoskeletal system: skeleton: bone and bones: bones of lower extremity: leg bones: tibia research abstracts see: musculoskeletal system: skeleton: bone and bones: bones of lower extremity: leg bones: tibia research

PUBMED ID PMID:

MEDLINE DATE:

Relationship between cartilage stiffness and dGEMRIC index: correlation and prediction. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of orthopaedic research : official publica

VOLUME: 25

Page Numbers: 904-12

Journal Abbreviation: J. Orthop. Res.

ISSN: 0736-0266

DAY: 3

MONTH: Jul

YEAR: 2007

Relationship between cartilage stiffness and dGEMRIC index: correlation and prediction. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8404726

Relationship between cartilage stiffness and dGEMRIC index: correlation and prediction. Keywords Mesh Terms:

KEYWORDS: Tibia

MESH TERMS: physiology

Chemical & Substance for Abstract: Relationship between cartilage stiffness and dGEMRIC index: correlation and prediction. Information

Substance Name: Gadolinium

Registry Number: 7440-54-2

Grant and Affiliation Information for Relationship between cartilage stiffness and dGEMRIC index: correlation and prediction.

AFFILIATION: New England Baptist Bone and Joint Institute, Boston, Massachusetts, USA.

Country: United States

AGENCY: United States NIAMS

GRANT: R01-AR-22021

ACRONYM: AR

MEDLINETA: J Orthop Res

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