Relationship between cancer and oral pemphigoid patients with antibodies to alpha6-integrin.

Relationship between cancer and oral pemphigoid patients with antibodies to alpha6-integrin. Research Abstract Details 

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Relationship between cancer and oral pemphigoid patients with antibodies to alpha6-integrin. Abstract Text:

Mohsin Malik,Hakan M ,William Christen,A Razzaque Ahmed,

BACKGROUND: Mucous membrane pemphigoid is an autoimmune mucocutaneous blistering disease. A subset, known as anti-epiligrin cicatricial pemphigoid is associated with a high risk for malignancy. Oral pemphigoid (OP) is limited to the oral cavity. The purpose of this study was to determine the association between malignancy and patients with OP with antibodies to alpha6-integrin subunit. METHODS: We determined the incidence of cancer in 72 patients with OP and compared it to the expected incidence using age and sex-specific rates of malignancy in the National Cancer Institute's Surveillance, Epidemiology, and End Results (NCI SEER) Registry. RESULTS: During a mean observation period of 9.1 years (range: 2.8-40), for 70, three OP patients developed malignancies. The expected number of cancers based on the NCI SEER Registry was 8.83. The relative risk for cancer in OP patients, with autoantibodies to alpha6-integrin, was 0.34 (95% CI, 0.07-0.99, P < 0.05). CONCLUSION: It appears that patients with OP, with antibodies to alpha6, may have a possible reduced relative risk for developing cancer.

Relationship between cancer and oral pemphigoid patients with antibodies to alpha6-integrin. Publishing Authors By Initials

M Malik,HM ,W Christen,AR Ahmed,

For similar epidemiologic factors: sex factors research abstracts see: epidemiologic factors: sex factors research

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Relationship between cancer and oral pemphigoid patients with antibodies to alpha6-integrin. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of oral pathology & medicine : official pu

VOLUME: 36

Page Numbers: 1-5

Journal Abbreviation: J. Oral Pathol. Med.

ISSN: 0904-2512

DAY: 3

MONTH: Jan

YEAR: 2007

Relationship between cancer and oral pemphigoid patients with antibodies to alpha6-integrin. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8911934

Relationship between cancer and oral pemphigoid patients with antibodies to alpha6-integrin. Keywords Mesh Terms:

KEYWORDS: Sex Factors

MESH TERMS: immunology

Chemical & Substance for Abstract: Relationship between cancer and oral pemphigoid patients with antibodies to alpha6-integrin. Information

Substance Name: Integrin alpha6

Registry Number: 0

Grant and Affiliation Information for Relationship between cancer and oral pemphigoid patients with antibodies to alpha6-integrin.

AFFILIATION: Department of Medicine, New England Baptist Hospital, Harvard School of Dental Medicine, Boston, MA, USA.

Country: Denmark

AGENCY: United States NEI

GRANT: R01-EY014228

ACRONYM: EY

MEDLINETA: J Oral Pathol Med

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