Relation of interleukin-6 and C-reactive protein levels to sinus maintenance after pharmacological cardioversion in persistent atrial fibrillation.

Relation of interleukin-6 and C-reactive protein levels to sinus maintenance after pharmacological cardioversion in persistent atrial fibrillation. Research Abstract Details 

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Relation of interleukin-6 and C-reactive protein levels to sinus maintenance after pharmacological cardioversion in persistent atrial fibrillation. Abstract Text:

Akira Fujiki,Tamotsu Sakamoto,Kunihiro Nishida,Koichi Mizumaki,Hiroshi Inoue,

OBJECT: The aim of this study was to investigate whether interleukin-6 (IL-6) and C-reactive protein (CRP) have significant relation to sinus maintenance after pharmacological conversion of long-lasting atrial fibrillation (AF) with respect to use of renin-angiotensin-aldosterone system (RAS) inhibitors. METHODS: We studied 35 consecutive patients with AF lasting > or =1 month who had successful pharmacological cardioversion with bepridil alone or in combination with aprindine. The IL-6 and CRP levels in plasma were measured after pharmacological restoration of sinus rhythm. RESULTS: During the 1-year follow-up period, sinus rhythm was maintained in 20 patients (Group I), and the other 15 patients had recurrence of AF (Group II). Both plasma levels of IL-6 and CRP were significantly lower in Group I than in Group II (IL-6: 1.19 +/- 0.51 versus 1.84 +/- 0.66 ng/L, P < 0.005; CRP: 0.59 +/- 0.40 versus 1.24 +/- 0.79 mg/L, P < 0.005). The use of RAS inhibitors and left atrial dimension and the left ventricular ejection fraction showed no differences between the 2 groups. There was significant positive correlation between levels of IL-6 and CRP. CONCLUSION: In long-lasting persistent AF, lower levels of IL-6 and CRP appear to be associated with maintenance of sinus rhythm after pharmacological cardioversion irrespective of the use of RAS inhibitors. Further studies are needed to clarify the role of RAS inhibitors.

Relation of interleukin-6 and C-reactive protein levels to sinus maintenance after pharmacological cardioversion in persistent atrial fibrillation. Publishing Authors By Initials

A Fujiki,T Sakamoto,K Nishida,K Mizumaki,H Inoue,

For similar natural sciences: time: time factors research abstracts see: natural sciences: time: time factors research

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Relation of interleukin-6 and C-reactive protein levels to sinus maintenance after pharmacological cardioversion in persistent atrial fibrillation. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of cardiovascular pharmacology

VOLUME: 50

Page Numbers: 264-6

Journal Abbreviation: J. Cardiovasc. Pharmacol.

ISSN: 0160-2446

DAY: 30

MONTH: Sep

YEAR: 2007

Relation of interleukin-6 and C-reactive protein levels to sinus maintenance after pharmacological cardioversion in persistent atrial fibrillation. Information

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LANGUAGE: eng

NlmUniqueID: 7902492

Relation of interleukin-6 and C-reactive protein levels to sinus maintenance after pharmacological cardioversion in persistent atrial fibrillation. Keywords Mesh Terms:

KEYWORDS: Time Factors

MESH TERMS: drug effects

Chemical & Substance for Abstract: Relation of interleukin-6 and C-reactive protein levels to sinus maintenance after pharmacological cardioversion in persistent atrial fibrillation. Information

Substance Name: C-Reactive Protein

Registry Number: 9007-41-4

Grant and Affiliation Information for Relation of interleukin-6 and C-reactive protein levels to sinus maintenance after pharmacological cardioversion in persistent atrial fibrillation.

AFFILIATION: Second Department of Internal Medicine, Faculty of Medicine, University of Toyama, Toyama, Japan. fujiki@med.u-toyoma.ac.jp

Country: United States

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MEDLINETA: J Cardiovasc Pharmacol

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