[Relation of genetic polymorphism of NQO1 and GSTT1 with risks of chronic benzene poisoning]

[Relation of genetic polymorphism of NQO1 and GSTT1 with risks of chronic benzene poisoning] Research Abstract Details 

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[Relation of genetic polymorphism of NQO1 and GSTT1 with risks of chronic benzene poisoning] Abstract Text:

Junxiang Wan,Jinxiu Shi,Jiru Guan,Rong Ye,Xiaoling Gao,Weiwei Liu,Lijian Hui,Duozhi Cao,Xipeng Jin,Gengxi Hu,Zhaolin Xia,

OBJECTIVE: To explore the relation between genetic polymorphisms of NQO1, GSTT1 and risks of chronic benzene poisoning (BP). METHODS: A case-control study was conducted. 152 BP patients and 152 workers occupationally exposed to benzene without poisoning manifestations were investigated. Polymerase chain reaction (PCR), denaturing high-performance liquid chromatography(DHPLC) and sequencing were used to detect the single nucleotide polymorphisms(SNPs) of the promoter and complete coding-region of NQO1 gene. Multiple PCR was used to detect GSTT1 genotype. RESULTS: In smoking population, there was 7.73-fold (95% CI: 1.71-34.97, P = 0.010) of risk in BP subjects carrying NQO1c. 609 T/T genotype, compared with those carrying C/C and C/T. genotype. In drinking population, the individuals carrying the 6th extron of NQO1c. 609 T/T homozygote genotype had a 11.00-fold(95% CI: 1.89-63.83, P = 0.005) risk of BP compared to those with NQO1c. 609 C/T and C/C genotypes. CONCLUSION: The subjects carrying NQO1c. 609 T/T genotype and together with the habit of smoking or drinking may be more susceptible to BP.

[Relation of genetic polymorphism of NQO1 and GSTT1 with risks of chronic benzene poisoning] Publishing Authors By Initials

J Wan,J Shi,J Guan,R Ye,X Gao,W Liu,L Hui,D Cao,X Jin,G Hu,Z Xia,

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[Relation of genetic polymorphism of NQO1 and GSTT1 with risks of chronic benzene poisoning] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua lao dong wei sheng zhi ye bing za zhi = Z

VOLUME: 20

Page Numbers: 340-3

Journal Abbreviation: Zhonghua Lao Dong Wei Sheng Zh

ISSN: 1001-9391

DAY: 25

MONTH: Oct

YEAR: 2002

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LANGUAGE: chi

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AFFILIATION: Department of Occupational Health, School of Public Health, Fudan University, Shanghai 200032, China.

Country: China

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MEDLINETA: Zhonghua Lao Dong Wei Sheng Zh

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