[Relation between pathologic tumor response to preoperative radiotherapy and the prognosis in patients with esophageal carcinoma]

[Relation between pathologic tumor response to preoperative radiotherapy and the prognosis in patients with esophageal carcinoma] Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

[Relation between pathologic tumor response to preoperative radiotherapy and the prognosis in patients with esophageal carcinoma] Abstract Text:

Guang-fei Ou,Mei Wang, Wang,Wei-bo Yin,Xian-zhi Gu,

OBJECTIVE: To analyze the relation between pathologic tumor response in preoperative radiotherapy and long-term survival in patients with esophageal carcinoma and the significance of radiosensitivity in the treatment of esophageal carcinoma. METHODS: 176 esophageal cancer patients received preoperative radiotherapy and tumor resection from 1977 to 1989. The radio-response was classified into severe, moderate and mild according to the tumor pathologic response to radiotherapy. 191 patients treated by surgery alone served as control. The relation between radiation response of tumor and long-term survival and disease free survival was analyzed. RESULTS: The 5-year survival rates of severe, moderate, mild and control groups were 60.7%, 46.4%, 21.1% and 38.8%. The survival was significantly improved in severe than moderate one (P = 0.029), moderate than mild group (P = 0.013) and severe than the control group (P = 0.000). It was only slightly improved in the moderate than control group (P = 0.295), but decreased in mild than the control group (P = 0.034). The 5-year disease-free survival (DFS) rates were 55.7%, 40.7%, 18.7% and 33.3% in severe, moderate, mild and control groups. The DFS was significantly improved in severe than moderate group (P = 0.029), moderate than mild group (P = 0.018), severe than the control group (P = 0.000 4). It was only slightly improved in moderate than the control group (P = 0.23), but decreased in the mild than the control group (P = 0.096). In the severe group, the proportion of stage T4, N1 lesion, TNM stage I-II and number of radical resection were 9.8%, 18%, 90.2%, and 90.2%. In the moderate group, they were 20.3%, 15.9%, 79.7% and 82.6%. In the mild group, they were 42.2%, 37.8%, 53.3% and 46.7%. In the control group, they were 50.3%, 40.8%, 37.7% and 77.5%. The rates of downstaging and surgical resection were improved only in severe and moderate groups (P < 0.01). CONCLUSION: The fact that only patients in whom severe radiation response are observed would appreciably benefit from preoperative radiotherapy whereas the others do not, illustrates that there might be no benefit of radiotherapy for radioresistant esophageal carcinoma. Radiosensitivity measurement before preoperative radiotherapy would be valuable for individualized treatment.

[Relation between pathologic tumor response to preoperative radiotherapy and the prognosis in patients with esophageal carcinoma] Publishing Authors By Initials

GF Ou,M Wang,LH Wang,WB Yin,XZ Gu,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

[Relation between pathologic tumor response to preoperative radiotherapy and the prognosis in patients with esophageal carcinoma] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua zhong liu za zhi [Chinese journal of onco

VOLUME: 25

Page Numbers: 278-81

Journal Abbreviation: Zhonghua Zhong Liu Za Zhi

ISSN: 0253-3766

DAY: 3

MONTH: May

YEAR: 2003

[Relation between pathologic tumor response to preoperative radiotherapy and the prognosis in patients with esophageal carcinoma] Information

Number of References:

LANGUAGE: chi

NlmUniqueID: 7910681

[Relation between pathologic tumor response to preoperative radiotherapy and the prognosis in patients with esophageal carcinoma] Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: [Relation between pathologic tumor response to preoperative radiotherapy and the prognosis in patients with esophageal carcinoma] Information

Substance Name:

Registry Number:

Grant and Affiliation Information for [Relation between pathologic tumor response to preoperative radiotherapy and the prognosis in patients with esophageal carcinoma]

AFFILIATION: Department of Radiation Oncology, Cancer Institute (Hospital), Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021, China.

Country: China

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Zhonghua Zhong Liu Za Zhi

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Relation between pathologic tumor response to preoperative radiotherapy and the prognosis in patients with esophageal carcinoma Related Publications

• Bone graft in the shape of human mandibular condyle reconstruction via seeding marrow-derived osteoblasts into porous coral in a nude mice model.
• [A discuss on risk factors of final height in 21-hydroxylase deficiency patients]
• [Assessment of sleep disorders in children with Tourette's syndrome]
• [Changes in the activities of enzymes involved in starch synthesis and accumulation in caryopsis of transgenic rice with antisense Wx gene]
• [Changes in the pulmonary function of factory workers exposure to terephthalic acid]
• [Clinical evaluation of two types of NiTi rotary instruments in preparation of root canals]
• [Comparative research on attenuation characteristics of human bladder cancer tissue at different wavelengths of laser and their linearly polarized laser in vitro]
• [Construction and expression in E. coli of single-chain F v fragment of antihuman activated platelets monoclonal antibody]
• [Culture and identification of human skin fibroblasts.]
• [Detection of IFN-gamma level in single CD8+ T cell]
• [Differentially expressed genes in hepatocellular carcinoma of tree shrew induced by different factors]
• [Effects of sodium nitroprusside on mitochondrial function of rye and wheat root tip under aluminum stress]
• [Human anti-HCMV neutralizing Fab antibody generated by phage display library]
• [IR and Raman spectroscopic studies on the complexes of ytterbium with pyran derivatives]
• [Induction of anti-tumor immunity by HSP gp96-peptide complexes]
• [Molecular genetic analysis of congenital lipoid adrenal hyperplasia]
• [Optical properties of human normal bladder tissue at five different wavelengths of laser and their linearly polarized laser irradiation in vitro]
• [Optical properties of human normal small intestine tissue with theoretical model of optics about biological tissues at Ar+ laser and 532 nm laser and their linearly polarized laser irradiation in vitro]
• [Prenatal diagnosis of glycogen storage disease Ia by screening for hot spot mutations in combination with the 1176 nucleotide polymorphism linkage analysis]
• [Production and some properties of a beta-glucanase from Trichoderma sp. GXC]
• [Purification and application of viral capsid antigen of Epstein-Barr virus]
• [Quantitative determination of insulin in microemulsion preparations by RP-HPLC]
• [Radial artery for coronary artery bypass grafting: operative techniques and early results]
• [Relation between pathologic tumor response to preoperative radiotherapy and the prognosis in patients with esophageal carcinoma]
• [Reporter genes transfer into human squamous cell carcinoma of larynx factor receptor mediated non-viral GE7 polypeptide delivery system with a new epidermal growth]
• [Research progress on the effect of zinc on behavior]
• [Solid phase extraction and room temperature phosphorimetry coupling technique and its application]
• [Study on the Raman spectra of ZYA system]
• [The applications of SERS to labeled immunoassay]
• [Value of intra-abdominal pressure monitoring in the prevention and treatment of multiple organ dysfunction syndrome]