Regulatory factor X4 variant 3: a transcription factor involved in brain development and disease.

Regulatory factor X4 variant 3: a transcription factor involved in brain development and disease. Research Abstract Details 

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Regulatory factor X4 variant 3: a transcription factor involved in brain development and disease. Abstract Text:

Donghui Zhang,Darryl C Zeldin,Perry J Blackshear,Donghui Zhang,Darryl C Zeldin,Perry J Blackshear,Donghui Zhang,Darryl C Zeldin,Perry J Blackshear,

Regulatory factor X4 variant 3 (RFX4_v3) is a recently identified transcription factor specifically expressed in the brain. Gene disruption in mice demonstrated that interruption of a single allele (heterozygous, +/-) prevented formation of the subcommissural organ (SCO), resulting in congenital hydrocephalus, whereas interruption of two alleles (homozygous, -/-) caused fatal failure of dorsal midline brain structure formation. These mutagenesis studies implicated RFX4_v3 in early brain development as well as the genesis of the SCO. Rfx4_v3 deficiency presumably causes abnormalities in brain by altering the expression levels of many genes that are crucial for brain morphogenesis, such as the signaling components in the Wnt, bone morphogenetic protein, and retinoic acid pathways. RFX4_v3 might affect these critical signaling pathways in brain development. Cx3cl1, a chemokine gene highly expressed in brain, was identified as a direct target for RFX4_v3, indicating that RFX4_v3 possesses trans-acting activity to stimulate gene expression. Rfx4_v3 is highly expressed in the suprachiasmatic nucleus and might be involved in regulating the circadian clock. One haplotype in RFX4_v3 gene is linked to a higher risk of bipolar disorder, suggesting that this protein might contribute to the pathogenesis of the disease. This Mini-Review describes our current knowledge about RFX4_v3, an important protein that appears to be involved in many aspects of brain development and disease.

Regulatory factor X4 variant 3: a transcription factor involved in brain development and disease. Publishing Authors By Initials

D Zhang,DC Zeldin,PJ Blackshear,D Zhang,DC Zeldin,PJ Blackshear,D Zhang,DC Zeldin,PJ Blackshear,

For similar proteins: transcription factors research abstracts see: proteins: transcription factors research

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Regulatory factor X4 variant 3: a transcription factor involved in brain development and disease. Journal Published:

PUBLICATION TYPE: Review

Journal: Journal of neuroscience research

VOLUME: 85

Page Numbers: 3515-22

Journal Abbreviation: J. Neurosci. Res.

ISSN: 0360-4012

DAY: 19

MONTH: Dec

YEAR: 2007

Regulatory factor X4 variant 3: a transcription factor involved in brain development and disease. Information

Number of References: 29

LANGUAGE: eng

NlmUniqueID: 7600111

Regulatory factor X4 variant 3: a transcription factor involved in brain development and disease. Keywords Mesh Terms:

KEYWORDS: Transcription Factors

MESH TERMS: metabolism

Chemical & Substance for Abstract: Regulatory factor X4 variant 3: a transcription factor involved in brain development and disease. Information

Substance Name: Transcription Factors

Registry Number: 0

Grant and Affiliation Information for Regulatory factor X4 variant 3: a transcription factor involved in brain development and disease.

AFFILIATION: Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, 111 Alexander Drive, Research Triangle Park, NC 27709, USA.

Country: United States

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MEDLINETA: J Neurosci Res

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