Regulation of tumor cell mitochondrial homeostasis by an organelle-specific Hsp90 chaperone network.

Regulation of tumor cell mitochondrial homeostasis by an organelle-specific Hsp90 chaperone network. Research Abstract Details 

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Regulation of tumor cell mitochondrial homeostasis by an organelle-specific Hsp90 chaperone network. Abstract Text:

Byoung Heon Kang,Janet Plescia,Takehiko Dohi,Jack Rosa,Stephen J Doxsey,Dario C Altieri,Byoung Heon Kang,Janet Plescia,Takehiko Dohi,Jack Rosa,Stephen J Doxsey,Dario C Altieri,

Molecular chaperones, especially members of the heat shock protein 90 (Hsp90) family, are thought to promote tumor cell survival, but this function is not well understood. Here, we show that mitochondria of tumor cells, but not most normal tissues, contain Hsp90 and its related molecule, TRAP-1. These chaperones interact with Cyclophilin D, an immunophilin that induces mitochondrial cell death, and antagonize its function via protein folding/refolding mechanisms. Disabling this pathway using novel Hsp90 ATPase antagonists directed to mitochondria causes sudden collapse of mitochondrial function and selective tumor cell death. Therefore, Hsp90-directed chaperones are regulators of mitochondrial integrity, and their organelle-specific antagonists may provide a previously undescribed class of potent anticancer agents.

Regulation of tumor cell mitochondrial homeostasis by an organelle-specific Hsp90 chaperone network. Publishing Authors By Initials

BH Kang,J Plescia,T Dohi,J Rosa,SJ Doxsey,DC Altieri,BH Kang,J Plescia,T Dohi,J Rosa,SJ Doxsey,DC Altieri,

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Regulation of tumor cell mitochondrial homeostasis by an organelle-specific Hsp90 chaperone network. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Cell

VOLUME: 131

Page Numbers: 257-70

Journal Abbreviation: Cell

ISSN: 0092-8674

DAY: 19

MONTH: Oct

YEAR: 2007

Regulation of tumor cell mitochondrial homeostasis by an organelle-specific Hsp90 chaperone network. Information

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LANGUAGE: eng

NlmUniqueID: 413066

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Grant and Affiliation Information for Regulation of tumor cell mitochondrial homeostasis by an organelle-specific Hsp90 chaperone network.

AFFILIATION: Department of Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: HL54131

ACRONYM: HL

MEDLINETA: Cell

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