Regulation of Triglyceride Metabolism. II. Function of mitochondrial GPAT1 in the regulation of triacylglycerol biosynthesis and insulin action.

Regulation of Triglyceride Metabolism. II. Function of mitochondrial GPAT1 in the regulation of triacylglycerol biosynthesis and insulin action. Research Abstract Details 

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Regulation of Triglyceride Metabolism. II. Function of mitochondrial GPAT1 in the regulation of triacylglycerol biosynthesis and insulin action. Abstract Text:

Maria R ,Tal M Lewin,Rosalind A Coleman,

GPAT1, one of four known glycerol-3-phosphate acyltransferase isoforms, is located on the mitochondrial outer membrane, allowing reciprocal regulation with carnitine palmitoyltransferase-1. GPAT1 is upregulated transcriptionally by insulin and SREBP-1c and downregulated acutely by AMP-activated protein kinase, consistent with a role in triacylglycerol synthesis. Knockout and overexpression studies suggest that GPAT1 is critical for the development of hepatic steatosis and that steatosis initiated by overexpression of GPAT1 causes hepatic, and perhaps also peripheral, insulin resistance. Future questions include the function of GPAT1 in relation to the other GPAT isoforms and whether the lipid intermediates synthesized by GPAT and downstream enzymes in the pathway of glycerolipid biosynthesis participate in intracellular signaling pathways.

Regulation of Triglyceride Metabolism. II. Function of mitochondrial GPAT1 in the regulation of triacylglycerol biosynthesis and insulin action. Publishing Authors By Initials

MR ,TM Lewin,RA Coleman,

For similar lipids: glycerides: triglycerides research abstracts see: lipids: glycerides: triglycerides research

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Regulation of Triglyceride Metabolism. II. Function of mitochondrial GPAT1 in the regulation of triacylglycerol biosynthesis and insulin action. Journal Published:

PUBLICATION TYPE: Review

Journal: American journal of physiology. Gastrointestinal a

VOLUME: 292

Page Numbers: G1195-9

Journal Abbreviation: Am. J. Physiol. Gastrointest.

ISSN: 0193-1857

DAY: 7

MONTH: 12

YEAR: 2006

Regulation of Triglyceride Metabolism. II. Function of mitochondrial GPAT1 in the regulation of triacylglycerol biosynthesis and insulin action. Information

Number of References: 25

LANGUAGE: eng

NlmUniqueID: 100901227

Regulation of Triglyceride Metabolism. II. Function of mitochondrial GPAT1 in the regulation of triacylglycerol biosynthesis and insulin action. Keywords Mesh Terms:

KEYWORDS: Triglycerides

MESH TERMS: biosynthesis

Chemical & Substance for Abstract: Regulation of Triglyceride Metabolism. II. Function of mitochondrial GPAT1 in the regulation of triacylglycerol biosynthesis and insulin action. Information

Substance Name: Glycerol-3-Phosphate O-Acyltransferase

Registry Number: EC 2.3.1.15

Grant and Affiliation Information for Regulation of Triglyceride Metabolism. II. Function of mitochondrial GPAT1 in the regulation of triacylglycerol biosynthesis and insulin action.

AFFILIATION: Instituto de Investigaciones Bioquímicas de La Plata (CONICET-UNLP), La Plata, Argentina.

Country: United States

AGENCY: United States FIC

GRANT: R03-TW06034

ACRONYM: TW

MEDLINETA: Am J Physiol Gastrointest Live

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