Regulation of TIMP gene expression in cell culture and during mouse embryogenesis.

Regulation of TIMP gene expression in cell culture and during mouse embryogenesis. Research Abstract Details 

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Regulation of TIMP gene expression in cell culture and during mouse embryogenesis. Abstract Text:

We have identified elements in the 5' region of the murine tissue inhibitor of metalloproteinase (TIMP) gene which control the response to serum, phorbol esters and transforming growth factor beta (TGF-beta) in cell culture. These elements lie between -858 and -601 relative to the translation initiation start site in the gene and are distinct from those that control expression in response to virus induction. The temporal and spatial expression of the TIMP gene was also analysed during mouse embryogenesis using in situ hybridization. A transgenic mouse line was constructed which expressed a TIMP/lac Z fusion gene. Using in situ beta-galactosidase assays we were able to compare the expression of the transgene with the endogenous gene. Thus we concluded that most of the sequences controlling in vivo expression of TIMP were present in the transgene and could be localised to the 5' region of the gene.

Regulation of TIMP gene expression in cell culture and during mouse embryogenesis. Publishing Authors By Initials

For similar proteins: tissue inhibitor of metalloproteinases research abstracts see: proteins: tissue inhibitor of metalloproteinases research

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Regulation of TIMP gene expression in cell culture and during mouse embryogenesis. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Matrix (Stuttgart, Germany). Supplement

VOLUME: 1

Page Numbers: 275-80

Journal Abbreviation:

ISSN: 0940-1199

DAY: 26

MONTH: 02

YEAR: 1992

Regulation of TIMP gene expression in cell culture and during mouse embryogenesis. Information

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LANGUAGE: eng

NlmUniqueID: 9312140

Regulation of TIMP gene expression in cell culture and during mouse embryogenesis. Keywords Mesh Terms:

KEYWORDS: Tissue Inhibitor of Metalloproteinases

MESH TERMS: biosynthesis

Chemical & Substance for Abstract: Regulation of TIMP gene expression in cell culture and during mouse embryogenesis. Information

Substance Name: Tissue Inhibitor of Metalloproteinases

Registry Number: 0

Grant and Affiliation Information for Regulation of TIMP gene expression in cell culture and during mouse embryogenesis.

AFFILIATION: Research Institute, Hospital for Sick Children, Canada.

Country: GERMANY

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MEDLINETA: Matrix Suppl

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