Regulation of the crab heartbeat by crustacean cardioactive peptide (CCAP): central and peripheral actions.

Regulation of the crab heartbeat by crustacean cardioactive peptide (CCAP): central and peripheral actions. Research Abstract Details 

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Regulation of the crab heartbeat by crustacean cardioactive peptide (CCAP): central and peripheral actions. Abstract Text:

Timothy J Fort,Keyla , Agricola,Vladimir Brezina,Mark W Miller,

In regulating neurophysiological systems, neuromodulators exert multiple actions at multiple sites in such a way as to control the activity in an integrated manner. We are studying how this happens in a simple central pattern generator (CPG)-effector system, the heart of the blue crab Callinectes sapidus. The rhythmic contractions of this heart are neurogenic, driven by rhythmic motor patterns generated by the cardiac ganglion (CG). In this study, we used anatomical and physiological methods to examine the sources and actions on the system of crustacean cardioactive peptide (CCAP). Immunohistochemical localization revealed a plexus of CCAP-immunoreactive fibers in the pericardial organs (POs), neurohemal structures from which blood-borne neurohormones reach the heart. Combined backfill and immunohistochemical experiments indicated that the CCAP in the POs originated from a large contralateral neuron in each thoracic neuromere. In physiological experiments, we examined the actions of exogenous CCAP on the intact working heart, on the semi-intact heart in which we could record the motor patterns as well as the muscle contractions, and on the isolated CG. CCAP had strong positive inotropic and chronotropic effects. Dissection of these effects in terms of dose dependency, time course, and the preparation type in which they occurred suggested that they were produced by the interaction of three primary actions of CCAP exerted both on the heart muscle and on the CG. We conclude that CCAP released from the POs as a neurohormone regulates the crab heart by multiple actions on both the central and peripheral components of this model CPG-effector system.

Regulation of the crab heartbeat by crustacean cardioactive peptide (CCAP): central and peripheral actions. Publishing Authors By Initials

TJ Fort,K ,HJ Agricola,V Brezina,MW Miller,

For similar peptides: neuropeptides research abstracts see: peptides: neuropeptides research

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Regulation of the crab heartbeat by crustacean cardioactive peptide (CCAP): central and peripheral actions. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of neurophysiology

VOLUME: 97

Page Numbers: 3407-20

Journal Abbreviation: J. Neurophysiol.

ISSN: 0022-3077

DAY: 15

MONTH: 02

YEAR: 2007

Regulation of the crab heartbeat by crustacean cardioactive peptide (CCAP): central and peripheral actions. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 375404

Regulation of the crab heartbeat by crustacean cardioactive peptide (CCAP): central and peripheral actions. Keywords Mesh Terms:

KEYWORDS: Neuropeptides

MESH TERMS: metabolism

Chemical & Substance for Abstract: Regulation of the crab heartbeat by crustacean cardioactive peptide (CCAP): central and peripheral actions. Information

Substance Name: crustacean cardioactive peptide

Registry Number: 0

Grant and Affiliation Information for Regulation of the crab heartbeat by crustacean cardioactive peptide (CCAP): central and peripheral actions.

AFFILIATION: Institute of Neurobiology and Department of Anatomy, University of Puerto Rico, 201 Blvd del Valle, San Juan, Puerto Rico 00901.

Country: United States

AGENCY: United States NCRR

GRANT: RR-03051

ACRONYM: RR

MEDLINETA: J Neurophysiol

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