Regulation of the activities of multifunctional Ca2+/calmodulin-dependent protein kinases.

Regulation of the activities of multifunctional Ca2+/calmodulin-dependent protein kinases. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Regulation of the activities of multifunctional Ca2+/calmodulin-dependent protein kinases. Abstract Text:

H Fujisawa,

Ca2+/calmodulin-dependent protein kinases (CaM-kinases) II, IV, and I play important roles as Ca2+ responsive multifunctional protein kinases in controlling a variety of cellular functions in response to an increase in intracellular Ca2+, and hence regulation of their activities is very important. CaM-kinase II is activated through autophosphorylation of threonine-286 (in the case of alpha isoform), and CaM-kinases IV and I are activated through phosphorylation of threonine-196 and 177, respectively, by CaM-kinase kinase. After activation, CaM-kinases II and IV lose their Ca2+/calmodulin-dependent activity upon autophosphorylation of threonine-305 and serine-332, respectively, in the absence of Ca2+, becoming Ca2+/calmodulin-independent forms. The activated CaM-kinases II, IV, and I are deactivated upon dephosphorylation of phosphothreonine-286, 196, and 177, respectively, by CaM-kinase phosphatase or other multifunctional protein phosphatases and restored to the original ground states. Thus, the activities of the three multifunctional CaM-kinases are regulated by phosphorylation and dephosphorylation.

Regulation of the activities of multifunctional Ca2+/calmodulin-dependent protein kinases. Publishing Authors By Initials

H Fujisawa,

For similar tissues: lymphoid tissue: thymus gland research abstracts see: tissues: lymphoid tissue: thymus gland research

PUBMED ID PMID:

MEDLINE DATE:

Regulation of the activities of multifunctional Ca2+/calmodulin-dependent protein kinases. Journal Published:

PUBLICATION TYPE: Review

Journal: Journal of biochemistry

VOLUME: 129

Page Numbers: 193-9

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Feb

YEAR: 2001

Regulation of the activities of multifunctional Ca2+/calmodulin-dependent protein kinases. Information

Number of References: 55

LANGUAGE: eng

NlmUniqueID: 376600

Regulation of the activities of multifunctional Ca2+/calmodulin-dependent protein kinases. Keywords Mesh Terms:

KEYWORDS: Thymus Gland

MESH TERMS: enzymology

Chemical & Substance for Abstract: Regulation of the activities of multifunctional Ca2+/calmodulin-dependent protein kinases. Information

Substance Name: Phosphoprotein Phosphatases

Registry Number: EC 3.1.3.16

Grant and Affiliation Information for Regulation of the activities of multifunctional Ca2+/calmodulin-dependent protein kinases.

AFFILIATION: Department of Biochemistry, Asahikawa Medical College, Asahikawa, Hokkaido 078-8510, Japan. fujisawa@asahikawa-med.ac.jp

Country: Japan

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Biochem

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Regulation of the activities of multifunctional Ca2+/calmodulin-dependent protein kinases Related Publications

• A Solitary Metastatic Lung Tumor from Thyroid Papillary Carcinoma Diagnosed by Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration (EBUS-TBNA): Report of a Case.
• A comparison of clinical features between chlamydial and non-chlamydial urethritis in men negative for gonococcal infection who attended a urological outpatient clinic in Japan.
• A conservative test for multiple comparison based on highly correlated test statistics.
• A novel neuropeptide (FRamide) family identified by a peptidomic approach in Hydra magnipapillata.
• Aberrant methylation of IL-12Rbeta2 gene in lung adenocarcinoma cells is associated with unfavorable prognosis.
• Assessment of gonadotropin therapy in male hypogonadotropic hypogonadism.
• Clinical outcome of surgical management for patients with renal cell carcinoma involving the inferior vena cava.
• Diversity of structural behavior in vertebrate conventional myosins complexed with actin.
• Endobronchial ultrasound-guided transbronchial needle aspiration for the treatment of central airway stenosis caused by a mediastinal cyst.
• Exploratory aspirin resistance trial in healthy Japanese volunteers (J-ART) using platelet aggregation as a measure of thrombogenicity.
• High-Pressure Solution X-ray Scattering of Protein Using a Hydrostatic Cell with Diamond Windows.
• Identification and characterization of CaMKP-N, nuclear calmodulin-dependent protein kinase phosphatase.
• Improved accuracy for predicting the Gleason score of prostate cancer by increasing the number of transrectal biopsy cores.
• Increased testicular 8-hydroxy-2'-deoxyguanosine in patients with varicocele.
• Interactions between Plexin-A2, Plexin-A4, and Semaphorin 6A Control Lamina-Restricted Projection of Hippocampal Mossy Fibers.
• Malignant pheochromocytoma with IVC thrombus.
• Posterior approach for retroperitoneal laparoscopic bilateral native nephrectomy in prone position: initial experience with four cases.
• Radical-scavenging activity of the reaction products of isoeugenol with thiol, thiophenol, mercaptothiazoline or mercaptomethylimidazole using the induction period method.
• Regulation of Ca(2+)/calmodulin-dependent protein kinase kinase alpha by cAMP-dependent protein kinase: I. Biochemical analysis.
• Regulation of Ca(2+)/calmodulin-dependent protein kinase kinase alpha by cAMP-dependent protein kinase: II. Mutational analysis.
• Regulation of the activities of multifunctional Ca2+/calmodulin-dependent protein kinases.
• Significance of lateral biopsy specimens during transrectal ultrasound-guided prostate biopsies in Japanese men.
• Significance of radical cystectomy for bladder cancer in patients over 80 years old.
• Studies on the phosphorylation of protein kinase B by Ca(2+)/calmodulin-dependent protein kinases.
• Substrate specificity of Ca(2+)/calmodulin-dependent protein kinase phosphatase: kinetic studies using synthetic phosphopeptides as model substrates.
• Synchronous alterations of Wnt and epidermal growth factor receptor signaling pathways through aberrant methylation and mutation in non small cell lung cancer.
• The aboral pore of hydra: evidence that the digestive tract of hydra is a tube not a sac.
• The evaluation of lymph node metastasis by endobronchial ultrasound-guided transbronchial needle aspiration: crucial for selection of surgical candidates with metastatic lung tumors.
• Transurethral drainage for prostatic abscess in a patient with metastatic testicular cancer undergoing systemic chemotherapy.
• Usefulness and problems of the urinary tract infection criteria for evaluating drug efficacy for complicated urinary tract infections.