Regulation of synaptic signalling by postsynaptic, non-glutamate receptor ion channels.

Regulation of synaptic signalling by postsynaptic, non-glutamate receptor ion channels. Research Abstract Details 

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Regulation of synaptic signalling by postsynaptic, non-glutamate receptor ion channels. Abstract Text:

Activation of glutamatergic synapses onto pyramidal neurons produces a synaptic depolarization as well as a buildup of intracellular calcium (Ca(2+)). The synaptic depolarization propagates through the dendritic arbor and can be detected at the soma with a recording electrode. Current influx through AMPA-type glutamate receptors (AMPARs) provides the depolarizing drive, and the amplitudes of synaptic potentials are generally thought to reflect the number and properties of these receptors at each synapse. In contrast, synaptically evoked Ca(2+) transients are limited to the spine containing the active synapse and result primarily from Ca(2+) influx through NMDA-type glutamate receptors (NMDARs). Here we review recent studies that reveal that both synaptic depolarizations and spine head Ca(2+) transients are strongly regulated by the activity of postsynaptic, non-glutamate receptor ion channels. In hippocampal pyramidal neurons, voltage- and Ca(2+)-gated ion channels located in dendritic spines open as downstream consequences of glutamate receptor activation and act within a complex signalling loop that feeds back to regulate synaptic signals. Dynamic regulation of these ion channels offers a powerful mechanism of synaptic plasticity that is independent of direct modulation of glutamate receptors.

Regulation of synaptic signalling by postsynaptic, non-glutamate receptor ion channels. Publishing Authors By Initials

For similar synaptic transmission research abstracts see: synaptic transmission research

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Regulation of synaptic signalling by postsynaptic, non-glutamate receptor ion channels. Journal Published:

PUBLICATION TYPE: Review

Journal: The Journal of physiology

VOLUME: 586

Page Numbers: 1475-80

Journal Abbreviation: J. Physiol. (Lond.)

ISSN: 1469-7793

DAY: 20

MONTH: 12

YEAR: 2007

Regulation of synaptic signalling by postsynaptic, non-glutamate receptor ion channels. Information

Number of References: 51

LANGUAGE: eng

NlmUniqueID: 266262

Regulation of synaptic signalling by postsynaptic, non-glutamate receptor ion channels. Keywords Mesh Terms:

KEYWORDS: Synaptic Transmission

MESH TERMS: physiology

Chemical & Substance for Abstract: Regulation of synaptic signalling by postsynaptic, non-glutamate receptor ion channels. Information

Substance Name: Receptors, N-Methyl-D-Aspartate

Registry Number: 0

Grant and Affiliation Information for Regulation of synaptic signalling by postsynaptic, non-glutamate receptor ion channels.

AFFILIATION: Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.

Country: England

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MEDLINETA: J Physiol

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