Regulation of secretion of osteoprotegerin in rat dental follicle cells.

Regulation of secretion of osteoprotegerin in rat dental follicle cells. Research Abstract Details 

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Regulation of secretion of osteoprotegerin in rat dental follicle cells. Abstract Text:

G E Wise,D Ding,S Yao,

Tooth eruption requires alveolar bone resorption and formation, both of which appear to be regulated by the dental follicle. Osteoclastogenesis needed for this bone resorption appears to occur as a result of a reduction in the expression of the osteoprotegerin (OPG) gene in the dental follicle at a specific time. This reduction in expression is mediated in vitro in the follicle cells by colony-stimulating factor-1 (CSF-1) and parathyroid hormone-related protein (PTHrP). Using enzyme-linked immunosorbent assays and immunoblotting, this study shows that the reduction in expression of OPG after incubation of the dental follicle cells in either CSF-1 or PTHrP also results in a reduction in its secretion. We also show, by laser capture microdissection, that PTHrP is expressed in vivo in the stellate reticulum such that it could inhibit OPG expression via a paracrine effect on the follicle. Bone formation is enhanced by OPG secretion, and incubation of the follicle cells with bone morphogenetic protein-2 (BMP-2) enhances OPG secretion. Thus, a reduction in secretion of the OPG protein at defined times may promote the osteoclastogenesis and alveolar bone resorption needed for eruption, and enhancement of OPG secretion at other times may promote alveolar bone formation.

Regulation of secretion of osteoprotegerin in rat dental follicle cells. Publishing Authors By Initials

GE Wise,D Ding,S Yao,

For similar peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research

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MEDLINE DATE:

Regulation of secretion of osteoprotegerin in rat dental follicle cells. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: European journal of oral sciences

VOLUME: 112

Page Numbers: 439-44

Journal Abbreviation: Eur. J. Oral Sci.

ISSN: 0909-8836

DAY: 19

MONTH: Oct

YEAR: 2004

Regulation of secretion of osteoprotegerin in rat dental follicle cells. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9504563

Regulation of secretion of osteoprotegerin in rat dental follicle cells. Keywords Mesh Terms:

KEYWORDS: Transforming Growth Factor beta

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Regulation of secretion of osteoprotegerin in rat dental follicle cells. Information

Substance Name: Macrophage Colony-Stimulating Factor

Registry Number: 81627-83-0

Grant and Affiliation Information for Regulation of secretion of osteoprotegerin in rat dental follicle cells.

AFFILIATION: Department of Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA. gwise@vetmed.lsu.edu

Country: Denmark

AGENCY: United States NIDCR

GRANT: DE08911-12

ACRONYM: DE

MEDLINETA: Eur J Oral Sci

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