Regulation of pyruvate kinase type M2 by A-Raf: a possible glycolytic stop or go mechanism.

Regulation of pyruvate kinase type M2 by A-Raf: a possible glycolytic stop or go mechanism. Research Abstract Details 

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Regulation of pyruvate kinase type M2 by A-Raf: a possible glycolytic stop or go mechanism. Abstract Text:

Sybille Mazurek,Hannes C A Drexler,Jakob Troppmair,Erich Eigenbrodt,Ulf R Rapp,Sybille Mazurek,Hannes C A Drexler,Jakob Troppmair,Erich Eigenbrodt,Ulf R Rapp,

Recently a link between A-Raf cellular energy homeostasis and synthetic pathways has been suggested through the identification of pyruvate kinase type M2 (M2-PK), a key glycolytic enzyme, as interaction partner of A-Raf In this study, we demonstrated that A-Raf is an important regulator of M2-PK function. In primary mouse fibroblasts, which are characterized by glutamine production and serine degradation, A-Raf induced dimerization and inactivation of M2-PK, thereby reducing conversion rates from glucose to lactate. In immortalized NIH3T3 fibroblasts, showing glutamine degradation and serine production, oncogenic A-Raf increased the highly active tetrameric form of M2-PK and favored glycolytic energy production. High serine levels thus may be responsible for the activation of M2-PK in A-Raf transformed NIH3T3 cells.

Regulation of pyruvate kinase type M2 by A-Raf: a possible glycolytic stop or go mechanism. Publishing Authors By Initials

S Mazurek,HC Drexler,J Troppmair,E Eigenbrodt,UR Rapp,S Mazurek,HC Drexler,J Troppmair,E Eigenbrodt,UR Rapp,

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MEDLINE DATE: 2007 Nov-Dec

Regulation of pyruvate kinase type M2 by A-Raf: a possible glycolytic stop or go mechanism. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Anticancer research

VOLUME: 27

Page Numbers: 3963-71

Journal Abbreviation: Anticancer Res.

ISSN: 0250-7005

DAY: 29

MONTH: 01

YEAR: 2008

Regulation of pyruvate kinase type M2 by A-Raf: a possible glycolytic stop or go mechanism. Information

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LANGUAGE: eng

NlmUniqueID: 8102988

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AFFILIATION: Institute of Biochemistry and Endocrinology, Veterinary Faculty, Justus-Liebig- University, Giessen, Germany. Sybille.Mazurek@vetmed.uni-giessen.de

Country: Greece

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MEDLINETA: Anticancer Res

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