Regulation of pain sensitivity in the central nervous system.

Regulation of pain sensitivity in the central nervous system. Research Abstract Details 

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Regulation of pain sensitivity in the central nervous system. Abstract Text:

K Hole,O G Berge,

Nociceptive information may be inhibited by stimulation of opiate receptors located presynaptically on primary afferent neurons. Sensory signals entering the spinal cord inhibit nociceptive signals by a non-opioid "gate" mechanism. Descending systems also modulate pain sensitivity at the spinal level. The descending 5-hydroxytryptamine (5-HT) system has a tonic inhibitory function, with diurnal fluctuations in intensity. The strong analgesic effects of electrical stimulation and morphine microinjections in certain brainstem structures is probably mediated by other descending systems. The ascending 5-HT system may influence the results of some complex tests for pain sensitivity by altering e.g. emotionality and habituation rate. Acupuncture analgesia involves opioid systems. In high frequency electroacupuncture and transcutaneous nerve stimulation, a non-opioid "gate" mechanism may predominate. Acute stress may produce analgesia by opioid as well as non-opioid mechanisms. The control of pain sensitivity is influenced by learning (e.g. biofeedback techniques and social factors), and may be affected in depression, mania and schizophrenia.

Regulation of pain sensitivity in the central nervous system. Publishing Authors By Initials

K Hole,OG Berge,

For similar organic chemicals: amines: biogenic amines: biogenic monoamines: tryptamines: serotonin research abstracts see: organic chemicals: amines: biogenic amines: biogenic monoamines: tryptamines: serotonin research

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Regulation of pain sensitivity in the central nervous system. Journal Published:

PUBLICATION TYPE: Review

Journal: Cephalalgia : an international journal of headache

VOLUME: 1

Page Numbers: 51-9

Journal Abbreviation: Cephalalgia

ISSN: 0333-1024

DAY: 11

MONTH: Mar

YEAR: 1981

Regulation of pain sensitivity in the central nervous system. Information

Number of References: 93

LANGUAGE: eng

NlmUniqueID: 8200710

Regulation of pain sensitivity in the central nervous system. Keywords Mesh Terms:

KEYWORDS: Serotonin

MESH TERMS: physiology

Chemical & Substance for Abstract: Regulation of pain sensitivity in the central nervous system. Information

Substance Name: Serotonin

Registry Number: 50-67-9

Grant and Affiliation Information for Regulation of pain sensitivity in the central nervous system.

AFFILIATION: Institute of Physiology, University of Bergen, Bergen, Norway.

Country: England

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MEDLINETA: Cephalalgia

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