Regulation of NF-kappaB-dependent gene expression by the POU domain transcription factor Oct-1.

Regulation of NF-kappaB-dependent gene expression by the POU domain transcription factor Oct-1. Research Abstract Details 

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Regulation of NF-kappaB-dependent gene expression by the POU domain transcription factor Oct-1. Abstract Text:

Nathaniel G dela Paz,Simos Simeonidis,Christopher Leo,David W Rose,Tucker Collins,

Maintenance of the cells of the vessel wall in a quiescent state is an important aspect of normal vascular physiology. Transcriptional repressors are widely believed to regulate this process, yet the exact factors involved and the mechanism of repression are not known. Here, we report that the POU domain transcription factor Oct-1 represses the expression of E-selectin and vascular cell adhesion molecule (VCAM-1), two cytokine-inducible, NF-kappaB-dependent endothelial-leukocyte adhesion molecules that participate in the leukocyte recruitment phase of the inflammatory response. Co-transfection and microinjection studies demonstrate that Oct-1 blocks tumor necrosis factor alpha-stimulated E-selectin and VCAM-1 expression. Gene expression arrays indicate that control of tumor necrosis factor alpha-induced, NF-kappaB-dependent gene expression by Oct-1 is promoter-specific. A DNA-binding mutant of Oct-1 represses NF-kappaB-dependent reporter gene expression. Biochemically, Oct-1 interacts with p65, suggesting that Oct-1 is involved in the regulation of NF-kappaB transactivation function. NF-kappaB-dependent gene expression is more pronounced in Oct-1-deficient than in wild-type murine embryonic fibroblasts, and reintroduction of human Oct-1 abolishes these differences. Finally, the cytokine interleukin-6 induces Oct-1 gene expression, providing a biologically relevant means by which NF-kappaB-dependent gene expression can be selectively reverted by Oct-1 to quiescent levels.

Regulation of NF-kappaB-dependent gene expression by the POU domain transcription factor Oct-1. Publishing Authors By Initials

NG dela Paz,S Simeonidis,C Leo,DW Rose,T Collins,

For similar membrane glycoproteins: cell adhesion molecules: vascular cell adhesion molecule-1 research abstracts see: membrane glycoproteins: cell adhesion molecules: vascular cell adhesion molecule-1 research

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Regulation of NF-kappaB-dependent gene expression by the POU domain transcription factor Oct-1. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: The Journal of biological chemistry

VOLUME: 282

Page Numbers: 8424-34

Journal Abbreviation: J. Biol. Chem.

ISSN: 0021-9258

DAY: 27

MONTH: 12

YEAR: 2006

Regulation of NF-kappaB-dependent gene expression by the POU domain transcription factor Oct-1. Information

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LANGUAGE: eng

NlmUniqueID: 2985121

Regulation of NF-kappaB-dependent gene expression by the POU domain transcription factor Oct-1. Keywords Mesh Terms:

KEYWORDS: Vascular Cell Adhesion Molecule-1

MESH TERMS: biosynthesis

Chemical & Substance for Abstract: Regulation of NF-kappaB-dependent gene expression by the POU domain transcription factor Oct-1. Information

Substance Name: Vascular Cell Adhesion Molecule-1

Registry Number: 0

Grant and Affiliation Information for Regulation of NF-kappaB-dependent gene expression by the POU domain transcription factor Oct-1.

AFFILIATION: Molecular Pathology Graduate Program, School of Medicine, University of California, San Diego, La Jolla, California 92093-0673, and Department of Pathology, Children's Hospital, Boston, MA 02115, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: HL-45462

ACRONYM: HL

MEDLINETA: J Biol Chem

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