Regulation of netrin-1 receptors by amphetamine in the adult brain.

Regulation of netrin-1 receptors by amphetamine in the adult brain. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Regulation of netrin-1 receptors by amphetamine in the adult brain. Abstract Text:

L Yetnikoff,C Labelle-Dumais,C Flores,L Yetnikoff,C Labelle-Dumais,C Flores,

Netrin-1 is a guidance cue molecule fundamental to the organization of neuronal connectivity during development. Netrin-1 and its receptors, deleted in colorectal cancer (DCC) and UNC-5 homologues (UNC-5), continue to be expressed in the adult brain, although neither their function nor the kinds of events that activate their expression are known. Two lines of evidence suggest a role for netrin-1 in amphetamine-induced dopamine plasticity in the adult. First, DCC is highly expressed by adult dopamine neurons. Second, adult mice with reduced DCC levels do not develop amphetamine-induced behavioral sensitization. To explore the role of netrin-1 in amphetamine-induced plasticity, we examined the effects of sensitizing treatment regimens of amphetamine on DCC and/or UNC-5 protein expression in the adult rat. These treatments produced striking and enduring increases in DCC and UNC-5 expression in the cell body, but not terminal regions, of the mesocorticolimbic dopamine system. Notably, neuroadaptations in the cell body region of mesocorticolimbic dopamine neurons underlie the development of sensitization to the effects of amphetamine. Furthermore, these localized amphetamine-induced changes were prevented by co-treatment with an N-methyl-d-aspartate receptor antagonist, a treatment known to block the development of amphetamine-induced sensitization of behavioral activation, dopamine release and motivated behavior. Using immunohistochemistry, we showed that both DCC and UNC-5 receptors are highly expressed by adult mesocorticolimbic dopamine neurons. These results provide the first evidence that repeated exposure to a stimulant drug such as amphetamine affects netrin-1 receptor expression in the adult brain. Taken together, our findings suggest that changes in netrin-1 receptor expression may play a role in the lasting effects of exposure to amphetamine and other stimulant drugs.

Regulation of netrin-1 receptors by amphetamine in the adult brain. Publishing Authors By Initials

L Yetnikoff,C Labelle-Dumais,C Flores,L Yetnikoff,C Labelle-Dumais,C Flores,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Regulation of netrin-1 receptors by amphetamine in the adult brain. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Neuroscience

VOLUME: 150

Page Numbers: 764-73

Journal Abbreviation: Neuroscience

ISSN: 0306-4522

DAY: 10

MONTH: 10

YEAR: 2007

Regulation of netrin-1 receptors by amphetamine in the adult brain. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7605074

Regulation of netrin-1 receptors by amphetamine in the adult brain. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Regulation of netrin-1 receptors by amphetamine in the adult brain. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Regulation of netrin-1 receptors by amphetamine in the adult brain.

AFFILIATION: Douglas Mental Health University Institute, Department of Psychiatry, McGill University, 6875 LaSalle Boulevard, Montreal, Quebec, Canada H4H 1R3.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Neuroscience

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Regulation of netrin-1 receptors by amphetamine in the adult brain Related Publications

• A controlled trial on chlorpromazine and promazine in the management of delirium tremens.
• A dynamical study of the Si(+) + H(2)O reaction.
• Acute hypoxia differentially affects the gamma-aminobutyric acid type A receptor alpha(1), alpha(2), beta(2), and gamma(2) subunit mRNA levels in the developing chick optic tectum: Stage-dependent sensitivity.
• Alterations in dendritic morphology of hippocampal neurons in adult rats after neonatal administration of N-omega-nitro-L-arginine.
• Assisted living nursing practice: the language of dementia: theories and interventions.
• Attachment theory and group psychotherapy.
• Blood contamination in children's saliva: prevalence, stability, and impact on the measurement of salivary cortisol, testosterone, and dehydroepiandrosterone.
• Critical evaluation of the colocalization between calcitonin gene-related peptide, substance P, transient receptor potential vanilloid subfamily type 1 immunoreactivities, and isolectin B4 binding in primary afferent neurons of the rat and mouse.
• Determination of pesticide residues in lettuce by gas chromatography with electron-capture detection.
• Enhanced apomorphine sensitivity and increased binding of dopamine D(2) receptors in nucleus accumbens in prepubertal rats after neonatal blockade of the dopamine D(3) receptors by (+)-S14297.
• Experimental endometriosis in the rat is correlated with colonic motor function alterations but not with bacterial load.
• Fall prevention in assisted living: assessment and strategies.
• Leave no asthmatic child behind: the cultural competency of asthma educational materials.
• Molecular and antigenic characterization of Brazilian bovine herpesvirus type 1 isolates recovered from the brain of cattle with neurological disease.
• OC11 Changes in Fibroblast Growth Factor-2 in Ovine Follicle Development.
• Oral clonidine as pre-anaesthetic medication in hypertensive patients.
• Pathology of pulmonary hypertension.
• Regulation of netrin-1 receptors by amphetamine in the adult brain.
• Simplified multiresidue method for determination of pesticide residues in lettuce by gas chromatography with nitrogen-phosphorus detection.
• Surgical results of the Hypoglossal-Facial nerve Jump Graft technique.
• THE ROLE OF DENTISTRY IN PUBLIC HEALTH PROGRAMS.
• The NtcA-regulated amtB gene is necessary for full methylammonium uptake activity in the cyanobacterium Synechococcus elongatus.
• The histochemical demonstration of glycogen by silver complexes.
• Unmet Needs for Specialty, Dental, Mental, and Allied Health Care among Children with Special Health Care Needs: Are There Racial/Ethnic Disparities?
• Video-assisted thoracic surgery (VATS) lobectomy: the evidence base.
• [Instructions concerning the method of smallpox inoculation and the method of curing this disease taking into consideration the nature and way of life of the Indians of Guatemala. Printed on order of the superior government. In the office of Don Ignacio B
• [Leptospirosis in Tingo María, Department of Huánuco, Peru. I. Study on man and domestic animals]
• [New Pseudomonas aeruginosa pyocinotypes in childhood infections]
• [Not Available.]
• [Not Available.]