Regulation of myeloid-specific calcium binding protein synthesis by cytosolic protein kinase C.

Regulation of myeloid-specific calcium binding protein synthesis by cytosolic protein kinase C. Research Abstract Details 

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Regulation of myeloid-specific calcium binding protein synthesis by cytosolic protein kinase C. Abstract Text:

T Koike,N Harada,T Yoshida,M Morikawa,

Two calcium binding proteins, MRP-8 and MRP-14, are specifically synthesized in human myeloid cells. This paper shows that Me2SO, all-trans-retinoic acid (RA) and 1 alpha,25-dihydroxyvitamin D3 (1 alpha,25(OH)2D3), but not 12-O-tetradecanoyl phorbol-13-acetate (PMA) are potent inducers of MRP-8/14 protein complex in human leukemic cells. Transforming growth factor-beta 1 (TGF-beta 1) is shown to enhance the inductive effect of RA and 1 alpha,25(OH)2D3. We have examined the possibility that MRP expression is regulated through the protein kinase pathway. Both cytosolic and membrane-bound protein kinase C (PKC) activities increased during differentiation by RA and 1 alpha,25(OH)2D3. PMA-treatment led to a decrease of cytosolic PKC activity and an increase of membrane-bound PKC activity in the presence of these differentiation inducers, while PMA alone resulted in low cytosolic and high membrane-bound PKC activities. PKC inhibitor H7 inhibited MRP synthesis in HL-60 cells treated with RA and 1 alpha,25(OH)2D3. These results suggest that cytosolic PKC activity may be involved in a stimulatory pathway of MRP synthesis and that protein phosphorylation reactions may play important roles in MRP expression during myelocytic differentiation.

Regulation of myeloid-specific calcium binding protein synthesis by cytosolic protein kinase C. Publishing Authors By Initials

T Koike,N Harada,T Yoshida,M Morikawa,

For similar cells: cells, cultured: tumor cells, cultured research abstracts see: cells: cells, cultured: tumor cells, cultured research

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Regulation of myeloid-specific calcium binding protein synthesis by cytosolic protein kinase C. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of biochemistry

VOLUME: 112

Page Numbers: 624-30

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Nov

YEAR: 1992

Regulation of myeloid-specific calcium binding protein synthesis by cytosolic protein kinase C. Information

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LANGUAGE: eng

NlmUniqueID: 376600

Regulation of myeloid-specific calcium binding protein synthesis by cytosolic protein kinase C. Keywords Mesh Terms:

KEYWORDS: Tumor Cells, Cultured

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Regulation of myeloid-specific calcium binding protein synthesis by cytosolic protein kinase C. Information

Substance Name: Protein Kinase C

Registry Number: EC 2.7.11.13

Grant and Affiliation Information for Regulation of myeloid-specific calcium binding protein synthesis by cytosolic protein kinase C.

AFFILIATION: Tokyo Institute for Immunopharmacology, Inc.

Country: JAPAN

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MEDLINETA: J Biochem

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