Regulation of Mycobacterium tuberculosis whiB3 in the mouse lung and macrophages.

Regulation of Mycobacterium tuberculosis whiB3 in the mouse lung and macrophages. Research Abstract Details 

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Regulation of Mycobacterium tuberculosis whiB3 in the mouse lung and macrophages. Abstract Text:

N Banaiee,W R Jacobs,J D Ernst,

Mycobacterium tuberculosis is a highly successful human pathogen, with approximately 2x10(9) individuals infected globally. To understand the responses of M. tuberculosis to the in vivo environment, we studied the in vivo regulation of M. tuberculosis genes whose M. marinum homologs are induced in chronically infected frog tissues. The expression of 16S rRNA was shown to remain constant in M. tuberculosis under in vivo and in vitro conditions and therefore could be used for internal normalization in quantitative reverse transcription-PCR assays. We found whiB3, a putative transcriptional regulator implicated in mediating tissue damage, to be maximally induced at 2 weeks postinfection in the lungs of wild-type and immunodeficient (gamma interferon receptor-/-, Rag1-/-, and tumor necrosis factor alpha-/-) mice. At later time points in wild-type mice, whiB3 induction was decreased and gradually declined over the course of infection. In immunodeficient mice, whiB3 induction declined rapidly and was completely abolished in moribund animals. whiB3 was also found to be induced in naïve bone marrow-derived macrophages after 6 h of infection. whiB3 expression in vivo and in vitro was found to be inversely correlated with bacterial density. These results indicate that M. tuberculosis regulates the expression of whiB3 in response to environmental signals present in vivo and are consistent with a model of regulation by quorum sensing.

Regulation of Mycobacterium tuberculosis whiB3 in the mouse lung and macrophages. Publishing Authors By Initials

N Banaiee,WR Jacobs,JD Ernst,

For similar bacterial infections and mycoses: bacterial infections: gram-positive bacterial infections: actinomycetales infections: mycobacterium infections: tuberculosis: tuberculosis, pulmonary research abstracts see: bacterial infections and mycoses: bacterial infections: gram-positive bacterial infections: actinomycetales infections: mycobacterium infections: tuberculosis: tuberculosis, pulmonary research

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Regulation of Mycobacterium tuberculosis whiB3 in the mouse lung and macrophages. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Infection and immunity

VOLUME: 74

Page Numbers: 6449-57

Journal Abbreviation: Infect. Immun.

ISSN: 0019-9567

DAY: 21

MONTH: 08

YEAR: 2006

Regulation of Mycobacterium tuberculosis whiB3 in the mouse lung and macrophages. Information

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LANGUAGE: eng

NlmUniqueID: 246127

Regulation of Mycobacterium tuberculosis whiB3 in the mouse lung and macrophages. Keywords Mesh Terms:

KEYWORDS: Tuberculosis, Pulmonary

MESH TERMS: microbiology

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Grant and Affiliation Information for Regulation of Mycobacterium tuberculosis whiB3 in the mouse lung and macrophages.

AFFILIATION: Division of Infectious Diseases, Department of Medicine, New York University School of Medicine, Smilow Research Center, 522 First Avenue, SML 901, New York, NY 10016, USA. banain01@med.nyu.edu

Country: United States

AGENCY: United States NIAID

GRANT: R01AI51242

ACRONYM: AI

MEDLINETA: Infect Immun

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