Regulation of mitochondrial oxidative phosphorylation through cell signaling.

Regulation of mitochondrial oxidative phosphorylation through cell signaling. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Regulation of mitochondrial oxidative phosphorylation through cell signaling. Abstract Text:

Maik Hüttemann,Icksoo Lee,Lobelia Samavati,Hong Yu,Jeffrey W Doan,Maik Hüttemann,Icksoo Lee,Lobelia Samavati,Hong Yu,Jeffrey W Doan,

The mitochondrial oxidative phosphorylation (OxPhos) system plays a key role in energy production, the generation of free radicals, and apoptosis. A lack of cellular energy, excessive radical production, and dysregulated apoptosis are found alone or in combination in most human diseases, including neurodegenerative diseases, stroke, cardiovascular disorders, ischemia/reperfusion, and cancer. In the context of its relevance to human disease, this article reviews current knowledge about the regulation of OxPhos with a focus on cell signaling and discusses identified phosphorylation sites with the aid of crystal structures of OxPhos complexes. Several recent studies have shown that all OxPhos components can be phosphorylated; even the small electron carrier cytochrome c is tyrosine phosphorylated in vivo. We propose that in higher organisms, in contrast to bacteria, cell signaling pathways are the main regulator of energy production, triggered for example by hormones. Pathways that have been identified to act on OxPhos include protein kinases A and C and growth factor activated receptor tyrosine kinase signaling. Present knowledge about kinases and phosphatases that execute signals at the level of the mitochondrial OxPhos system, and newly emerging concepts, such as the translocation of kinases to the mitochondria upon stimulation of a signaling pathway, are discussed.

Regulation of mitochondrial oxidative phosphorylation through cell signaling. Publishing Authors By Initials

M Hüttemann,I Lee,L Samavati,H Yu,JW Doan,M Hüttemann,I Lee,L Samavati,H Yu,JW Doan,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Regulation of mitochondrial oxidative phosphorylation through cell signaling. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Biochimica et biophysica acta

VOLUME: 1773

Page Numbers: 1701-20

Journal Abbreviation: Biochim. Biophys. Acta

ISSN: 0006-3002

DAY: 31

MONTH: Dec

YEAR: 2007

Regulation of mitochondrial oxidative phosphorylation through cell signaling. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 217513

Regulation of mitochondrial oxidative phosphorylation through cell signaling. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Regulation of mitochondrial oxidative phosphorylation through cell signaling. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Regulation of mitochondrial oxidative phosphorylation through cell signaling.

AFFILIATION: Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201, USA. mhuttema@med.wayne.edu

Country: Netherlands

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Biochim Biophys Acta

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Regulation of mitochondrial oxidative phosphorylation through cell signaling Related Publications

• Chronic lymphatic leukemia.
• Colorectal cancer screening in vietnamese americans.
• Commentary on "increasing minority participation in clinical research": a white paper from the endocrine society.
• Hemophilia; current theories and successful medical management in traumatic and surgical crises.
• Hypersplenism.
• Irreversible toxic inclusion body anemia; a rarely recognized syndrome; clinical and experimental studies.
• OP22.02: Gelatin seal of fetoscopic access port following laser photocoagulation in Twin Twin Transfusion syndrome.
• Primary cutaneous malignant melanoma.
• Regulation of mitochondrial oxidative phosphorylation through cell signaling.
• Results from a Community-based Occupational Health Survey of Vietnamese-American Nail Salon Workers.
• Specialization of physicians levels and trends in some industrialized countries.
• Splenectomy in pregnancy, its hematologic indications and obstetric management.
• The cancer challenge.
• The cellular and humoral factors influencing constitutional resistance and the development and control of local lesions.
• [The International Symposium of Lisbon: an overview]