Regulation of luteinizing hormone receptor mRNA expression by a specific RNA binding protein in the ovary.

Regulation of luteinizing hormone receptor mRNA expression by a specific RNA binding protein in the ovary. Research Abstract Details 

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Regulation of luteinizing hormone receptor mRNA expression by a specific RNA binding protein in the ovary. Abstract Text:

K M J Menon,Anil K Nair,Lei Wang,Helle Peegel,

The expression of LH receptor mRNA shows significant changes during different physiological states of the ovary. Previous studies from our laboratory have identified a post-transcriptional mechanism by which LH receptor mRNA is regulated following preovulatory LH surge or in response to hCG administration. A specific binding protein, identified as mevalonate kinase, binds to the open reading frame of LH receptor mRNA. The protein binding site is localized to nucleotides 203-220 of the LH receptor mRNA and exhibits a high degree of specificity. The expression levels of the protein show an inverse relationship to the LH receptor mRNA levels. The hCG-induced down-regulation of LH receptor mRNA can be mimicked by increasing the intracellular levels of cyclic AMP by a phosphodiesterase inhibitor. An in vitro mRNA decay assay showed that addition of the binding protein to the decay system caused accelerated LH receptor mRNA decay. Our results therefore show that LH receptor mRNA expression in the ovary is regulated post-transcriptionally by altering the rate of mRNA degradation by a specific mRNA binding protein.

Regulation of luteinizing hormone receptor mRNA expression by a specific RNA binding protein in the ovary. Publishing Authors By Initials

KM Menon,AK Nair,L Wang,H Peegel,

For similar natural sciences: time: time factors research abstracts see: natural sciences: time: time factors research

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Regulation of luteinizing hormone receptor mRNA expression by a specific RNA binding protein in the ovary. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Molecular and cellular endocrinology

VOLUME: 260-262

Page Numbers: 109-16

Journal Abbreviation: Mol. Cell. Endocrinol.

ISSN: 0303-7207

DAY: 19

MONTH: 10

YEAR: 2006

Regulation of luteinizing hormone receptor mRNA expression by a specific RNA binding protein in the ovary. Information

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LANGUAGE: eng

NlmUniqueID: 7500844

Regulation of luteinizing hormone receptor mRNA expression by a specific RNA binding protein in the ovary. Keywords Mesh Terms:

KEYWORDS: Time Factors

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Regulation of luteinizing hormone receptor mRNA expression by a specific RNA binding protein in the ovary. Information

Substance Name: mevalonate kinase

Registry Number: EC 2.7.1.36

Grant and Affiliation Information for Regulation of luteinizing hormone receptor mRNA expression by a specific RNA binding protein in the ovary.

AFFILIATION: Department of Obstetrics and Gynecology, The University of Michigan Medical School, 6428 Medical Science I, 1150 W. Medical Center Drive, Ann Arbor, MI 48109-0617, United States. kmjmenon@umich.edu

Country: Ireland

AGENCY: United States NICHD

GRANT: R37 HD 06656

ACRONYM: HD

MEDLINETA: Mol Cell Endocrinol

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