Regulation of ion transport and blood pressure by cytochrome p450 monooxygenases.

Regulation of ion transport and blood pressure by cytochrome p450 monooxygenases. Research Abstract Details 

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Regulation of ion transport and blood pressure by cytochrome p450 monooxygenases. Abstract Text:

Jorge H Capdevila,

PURPOSE OF REVIEW: Past and recent studies of the cytochrome P450 monooxygenase branch of the arachidonate cascade establish a role for this metabolic pathway in the regulation of vascular tone and tubular ion transport. Functional and electrophysiology studies indicate that the P450 eicosanoids participate in the regulation of vascular potassium and renal sodium channels, and of systemic blood pressures. RECENT FINDINGS: Associations between genetically controlled alterations in blood pressure and the activity or transcriptional regulation of renal Cyp2c arachidonic acid epoxygenases and Cyp4a omega-hydroxylases document a role for these enzymes in the pathophysiology of hypertension--a leading cause of cardiovascular, cerebral, and renal morbidity and mortality. Associations between a functional variant of the human CYP4A11 gene and hypertension suggest a potential role for this gene as a determinant of polygenic blood pressure control in humans. SUMMARY: These results provide new understandings of the role of P450s in renal physiology, as well as conceptually novel approaches for studies of the molecular basis of human hypertension that could lead to new strategies for the early diagnosis and clinical management of this devastating disease.

Regulation of ion transport and blood pressure by cytochrome p450 monooxygenases. Publishing Authors By Initials

JH Capdevila,

For similar proteins: carrier proteins: membrane transport proteins: ion channels: sodium channels research abstracts see: proteins: carrier proteins: membrane transport proteins: ion channels: sodium channels research

PUBMED ID PMID:

MEDLINE DATE:

Regulation of ion transport and blood pressure by cytochrome p450 monooxygenases. Journal Published:

PUBLICATION TYPE: Review

Journal: Current opinion in nephrology and hypertension

VOLUME: 16

Page Numbers: 465-70

Journal Abbreviation: Curr. Opin. Nephrol. Hypertens

ISSN: 1062-4821

DAY: 3

MONTH: Sep

YEAR: 2007

Regulation of ion transport and blood pressure by cytochrome p450 monooxygenases. Information

Number of References: 59

LANGUAGE: eng

NlmUniqueID: 9303753

Regulation of ion transport and blood pressure by cytochrome p450 monooxygenases. Keywords Mesh Terms:

KEYWORDS: Sodium Channels

MESH TERMS: chemistry

Chemical & Substance for Abstract: Regulation of ion transport and blood pressure by cytochrome p450 monooxygenases. Information

Substance Name: CYP4A11 protein, human

Registry Number: EC 1.14.15.3

Grant and Affiliation Information for Regulation of ion transport and blood pressure by cytochrome p450 monooxygenases.

AFFILIATION: Department of Medicine, Vanderbilt University Medical School, Nashville, Tennessee 37232, USA.

Country: England

AGENCY: United States PHS

GRANT: 38226

ACRONYM:

MEDLINETA: Curr Opin Nephrol Hypertens

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