Regulation of intravenous cocaine self-administration in rats selectively bred for high (HiS) and low (LoS) saccharin intake.

Regulation of intravenous cocaine self-administration in rats selectively bred for high (HiS) and low (LoS) saccharin intake. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Regulation of intravenous cocaine self-administration in rats selectively bred for high (HiS) and low (LoS) saccharin intake. Abstract Text:

Marilyn E Carroll,Marissa M Anderson,Andrew D Morgan,

RATIONALE: Rats selectively bred for high saccharin (HiS) intake consume more alcohol and acquire intravenous (i.v.) cocaine self-administration more rapidly than their low saccharin (LoS)-consuming counterparts. The present experiment was designed to determine whether HiS and LoS rats differed in other aspects of drug abuse. OBJECTIVE: The purpose of the present experiment was to use a two-lever dose self-selection procedure to investigate the regulation/dysregulation of i.v. cocaine self-administration in female HiS and LoS rats. MATERIALS AND METHODS: HiS and LoS rats were trained to self-administer eight different doses of cocaine during daily 5-h sessions, with the cocaine doses ranging from 0.2 to 1.6 mg/kg in steps of 0.2 mg/kg. The dose size increased after a response on one lever (infusion duration lengthened by 3 s) and decreased after a response on the other lever (infusion duration shortened by 3 s), with a lower limit of 0 s and with an upper limit of 24 s (a corresponding range of 0 to 1.6 mg/kg); the animals increased or decreased their self-administered dose in nine discrete steps. RESULTS: The HiS rats showed less precise regulation of their postinfusion interval (PII) than LoS rats based on the size of the previously self-administered cocaine dose. Correlations between these variables were lower for HiS than for LoS rats during the acquisition and maintenance phases, and HiS rats had lower PIIs than LoS rats after many of the cocaine doses. The HiS rats also self-administered significantly more cocaine infusions during the maintenance phase than the LoS rats, especially at the highest dose. CONCLUSIONS: These data indicate that HiS rats are more likely to self-administer more cocaine infusions, at higher doses, and with less precise dose-time regulation than LoS rats. Thus, rats selectively bred for HiS showed less inhibitory control over their cocaine intake than LoS rats, suggesting that a genetic predisposition for saccharin preference is related to the rewarding effects of i.v. cocaine.

Regulation of intravenous cocaine self-administration in rats selectively bred for high (HiS) and low (LoS) saccharin intake. Publishing Authors By Initials

ME Carroll,MM Anderson,AD Morgan,

For similar natural sciences: time: time factors research abstracts see: natural sciences: time: time factors research

PUBMED ID PMID:

MEDLINE DATE:

Regulation of intravenous cocaine self-administration in rats selectively bred for high (HiS) and low (LoS) saccharin intake. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Psychopharmacology

VOLUME: 190

Page Numbers: 331-41

Journal Abbreviation: Psychopharmacology (Berl.)

ISSN: 0033-3158

DAY: 12

MONTH: 12

YEAR: 2006

Regulation of intravenous cocaine self-administration in rats selectively bred for high (HiS) and low (LoS) saccharin intake. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7608025

Regulation of intravenous cocaine self-administration in rats selectively bred for high (HiS) and low (LoS) saccharin intake. Keywords Mesh Terms:

KEYWORDS: Time Factors

MESH TERMS: administration & dosage

Chemical & Substance for Abstract: Regulation of intravenous cocaine self-administration in rats selectively bred for high (HiS) and low (LoS) saccharin intake. Information

Substance Name: Saccharin

Registry Number: 81-07-2

Grant and Affiliation Information for Regulation of intravenous cocaine self-administration in rats selectively bred for high (HiS) and low (LoS) saccharin intake.

AFFILIATION: Department of Psychiatry, University of Minnesota, MMC 392, Minneapolis, MN, 55455, USA. mcarroll@umn.edu

Country: Germany

AGENCY: United States NIDA

GRANT: T32 DA007097

ACRONYM: DA

MEDLINETA: Psychopharmacology (Berl)

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Regulation of intravenous cocaine self-administration in rats selectively bred for high HiS and low LoS saccharin intake Related Publications

• A Methodology for Comparing Results from Two Image Registration Systems used in MR-based Radiotherapy.
• A computer model to simulate control of parasitic gastroenteritis in sheep on UK farms.
• A left upper lobe tumour mimicking tracheal stenosis on plain chest x-ray.
• A role for mitochondrial dysfunction in perpetuating radiation-induced genomic instability.
• Abortive activation precedes functional deletion of CD8+ T cells following encounter with self-antigens expressed by resting B cells in vivo.
• An Introduction to Dermatological Surgery, 2nd edn.
• BMPs mediate lateral inhibition at successive stages in feather tract development.
• Barbiturates for acute neurological and neurosurgical emergencies - do they still have a role?
• Behavioral and electrophysiological evidence for opioid tolerance in adolescent rats.
• Cbln1 is essential for interaction-dependent secretion of Cbln3.
• Cdk and APC activities limit the spindle-stabilizing function of Fin1 to anaphase.
• Dysarthria and dysphagia following treatment for a fourth ventricle choroid plexus papilloma.
• Enhanced antitumor activity of murine-human hybrid T-cell receptor (TCR) in human lymphocytes is associated with improved pairing and TCR/CD3 stability.
• FEV(1) or peak flow for measuring airflow obstruction in primary care Is it a useful debate or just missing the point?
• Focal adhesion signaling is required for myometrial ERK activation and contractile phenotype switch before labor.
• Immune, health and endocrine characteristics of depressed postpartum mothers.
• Internet chat rooms: connecting with a new generation of young men of color at risk for HIV infection who have sex with other men.
• Mitochondrial dysfunction, persistently elevated levels of reactive oxygen species and radiation-induced genomic instability: a review.
• Mitochondrial respiration and reactive oxygen species in C. elegans.
• Off-pump repair of a post-infarct ventricular septal defect: the 'Hamburger procedure'.
• Parenteral nutrition in the preterm infant.
• RAD51 homologous recombination repair gene haplotypes and risk of acute myeloid leukaemia.
• Radioimmunoassay for the quantitative determination of quinine in cultured plant tissues.
• Regulation of intravenous cocaine self-administration in rats selectively bred for high (HiS) and low (LoS) saccharin intake.
• Sarcoptes scabiei (Acari: Sarcoptidae) mite extract modulates expression of cytokines and adhesion molecules by human dermal microvascular endothelial cells.
• Science signals a new understanding of marihuana.
• Sulfated signal from ASJ sensory neurons modulates stomatin-dependent coordination in Caenorhabditis elegans.
• Targeted and nontargeted effects of low-dose ionizing radiation on delayed genomic instability in human cells.
• Temporal mRNA profiles of inflammatory mediators in the murine 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrimidine model of Parkinson's disease.
• Vaccination of Tamarin with Recombinant Vaccinia Virus Expressing Epstein Barr Virus (EBV) Latent Proteins.