Regulation of interactions of Gram-negative bacterial endotoxins with mammalian cells.

Regulation of interactions of Gram-negative bacterial endotoxins with mammalian cells. Research Abstract Details 

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Regulation of interactions of Gram-negative bacterial endotoxins with mammalian cells. Abstract Text:

Theresa L Gioannini,Jerrold P Weiss,Theresa L Gioannini,Jerrold P Weiss,Theresa L Gioannini,Jerrold P Weiss,

Host defense against many invading Gram-negative bacteria (GNB) depends on innate immune recognition of endotoxin (lipopolysaccharides, LPS), unique surface glycolipids of GNB. Host responses to endotoxin must be highly sensitive but self-limited. In mammals, optimal sensitivity is achieved by ordered interactions of endotoxin with several different extracellular and cell surface proteins-the LPS-binding protein (LBP), CD14, MD-2, and Toll-like receptor (TLR) 4-reflecting the requirement for specific protein-endotoxin and protein-protein interactions. This complex reaction pathway also provides many ways to attenuate endotoxin-driven inflammation and can explain how differences in endotoxin structure, either intrinsic among GNB or induced by metabolic remodeling, can alter host responsiveness and thus the outcome of host-GNB interactions. Major goals of our research are to better understand: (1) the structural bases of specific host-endotoxin interactions; (2) functional diversity among host endotoxin-binding proteins; and (3) how the actions of various endotoxin-binding proteins are regulated to permit optimal host responses to GNB infection. In addition, the identification of a water-soluble endotoxin:MD-2 complex that, depending on the structure of endotoxin or MD-2, has potent TLR4 agonist or antagonist properties suggests novel pharmacologic approaches to immuno-modulation.

Regulation of interactions of Gram-negative bacterial endotoxins with mammalian cells. Publishing Authors By Initials

TL Gioannini,JP Weiss,TL Gioannini,JP Weiss,TL Gioannini,JP Weiss,

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Regulation of interactions of Gram-negative bacterial endotoxins with mammalian cells. Journal Published:

PUBLICATION TYPE: Review

Journal: Immunologic research

VOLUME: 39

Page Numbers: 249-60

Journal Abbreviation: Immunol. Res.

ISSN: 0257-277X

DAY: 5

MONTH: 10

YEAR: 2007

Regulation of interactions of Gram-negative bacterial endotoxins with mammalian cells. Information

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LANGUAGE: eng

NlmUniqueID: 8611087

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Grant and Affiliation Information for Regulation of interactions of Gram-negative bacterial endotoxins with mammalian cells.

AFFILIATION: The Inflammation Program, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, 2501 Crosspark Rd, Coralville, Iowa City, IA 52241, USA.

Country: United States

AGENCY: United States PHS

GRANT: P0144642

ACRONYM: AI

MEDLINETA: Immunol Res

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