Regulation of in situ to invasive breast carcinoma transition.

Regulation of in situ to invasive breast carcinoma transition. Research Abstract Details 

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Regulation of in situ to invasive breast carcinoma transition. Abstract Text:

The transition of ductal carcinoma in situ (DCIS) to invasive carcinoma is a poorly understood key event in breast tumor progression. Here, we analyzed the role of myoepithelial cells and fibroblasts in the progression of in situ carcinomas using a model of human DCIS and primary breast tumors. Progression to invasion was promoted by fibroblasts and inhibited by normal myoepithelial cells. Molecular profiles of isolated luminal epithelial and myoepithelial cells identified an intricate interaction network involving TGFbeta, Hedgehog, cell adhesion, and p63 required for myoepithelial cell differentiation, the elimination of which resulted in loss of myoepithelial cells and progression to invasion.

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Regulation of in situ to invasive breast carcinoma transition. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Cancer cell

VOLUME: 13

Page Numbers: 394-406

Journal Abbreviation: Cancer Cell

ISSN: 1535-6108

DAY: 5

MONTH: May

YEAR: 2008

Regulation of in situ to invasive breast carcinoma transition. Information

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LANGUAGE: eng

NlmUniqueID: 101130617

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Grant and Affiliation Information for Regulation of in situ to invasive breast carcinoma transition.

AFFILIATION: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA.

Country: United States

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MEDLINETA: Cancer Cell

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