Regulation of hepatocyte apoptosis by oxidative stress.

Regulation of hepatocyte apoptosis by oxidative stress. Research Abstract Details 

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Regulation of hepatocyte apoptosis by oxidative stress. Abstract Text:

Rajat Singh,Mark J Czaja,

Oxidative stress has been implicated as the mechanism of hepatocyte injury from numerous agents. Although reactive oxygen species injure cells by the modification of critical cellular macromolecules, recent studies have demonstrated the mechanistic involvement of oxidant stress-induced alterations in signal transduction cascades. Studies in menadione-treated hepatocytes have demonstrated differential effects of mitogen-activated protein kinase activation on hepatocyte death from acute oxidative stress. Activation of the extracellular signal-regulated kinase pathway 1/2 (ERK1/2) confers hepatocyte resistance to death whereas sustained c-Jun N-terminal kinase (JNK)/c-Jun/AP-1 activation promotes apoptosis. Redundant protective signals such as the protein kinase C/protein kinase D pathways also downregulate the JNK/c-Jun/AP-1 cascade and provide resistance to cell death. Although ERK1/2 overactivation also acts as a protective response to chronic oxidative stress, enhanced activation of this kinase sensitizes hepatocytes to death from free fatty acids in this setting. The outcome from challenge with an oxidative stress, therefore, depends on the integration of a series of signaling cascades that both protect against and promote hepatocyte apoptosis.

Regulation of hepatocyte apoptosis by oxidative stress. Publishing Authors By Initials

R Singh,MJ Czaja,

For similar biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research abstracts see: biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research

PUBMED ID PMID:

MEDLINE DATE:

Regulation of hepatocyte apoptosis by oxidative stress. Journal Published:

PUBLICATION TYPE: Review

Journal: Journal of gastroenterology and hepatology

VOLUME: 22 Suppl 1

Page Numbers: S45-8

Journal Abbreviation: J. Gastroenterol. Hepatol.

ISSN: 0815-9319

DAY: 3

MONTH: Jun

YEAR: 2007

Regulation of hepatocyte apoptosis by oxidative stress. Information

Number of References: 13

LANGUAGE: eng

NlmUniqueID: 8607909

Regulation of hepatocyte apoptosis by oxidative stress. Keywords Mesh Terms:

KEYWORDS: Signal Transduction

MESH TERMS: physiology

Chemical & Substance for Abstract: Regulation of hepatocyte apoptosis by oxidative stress. Information

Substance Name: Mitogen-Activated Protein Kinases

Registry Number: EC 2.7.1.37

Grant and Affiliation Information for Regulation of hepatocyte apoptosis by oxidative stress.

AFFILIATION: Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

Country: Australia

AGENCY: United States NIDDK

GRANT: DK61498

ACRONYM: DK

MEDLINETA: J Gastroenterol Hepatol

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