Regulation of Helicobacter pylori cagA expression in response to salt.

Regulation of Helicobacter pylori cagA expression in response to salt. Research Abstract Details 

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Regulation of Helicobacter pylori cagA expression in response to salt. Abstract Text:

John T Loh,Victor J Torres,Timothy L Cover,

Helicobacter pylori infection and a high dietary salt intake are risk factors for the development of gastric adenocarcinoma. In this study, we tested the hypothesis that high salt concentrations might alter gene expression in H. pylori. Transcriptional profiling experiments indicated that the expression of multiple H. pylori genes, including cagA, was regulated in response to the concentrations of sodium chloride present in the bacterial culture medium. Increased expression of cagA in response to high salt conditions was confirmed by the use of transcriptional reporter strains and by immunoblotting. H. pylori CagA is translocated into gastric epithelial cells via a type IV secretion pathway, and on entry into target cells, CagA undergoes tyrosine phosphorylation and causes multiple cellular alterations. Coculture of gastric epithelial cells with H. pylori grown under high salt conditions resulted in increased tyrosine-phosphorylated CagA and increased secretion of interleukin-8 by the epithelial cells compared with coculture of the cells with H. pylori grown under low salt conditions. Up-regulation of H. pylori cagA expression in response to high salt concentrations may be a factor that contributes to the development of gastric adenocarcinoma.

Regulation of Helicobacter pylori cagA expression in response to salt. Publishing Authors By Initials

JT Loh,VJ Torres,TL Cover,

For similar genetic processes: gene expression regulation: up-regulation research abstracts see: genetic processes: gene expression regulation: up-regulation research

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Regulation of Helicobacter pylori cagA expression in response to salt. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Cancer research

VOLUME: 67

Page Numbers: 4709-15

Journal Abbreviation: Cancer Res.

ISSN: 0008-5472

DAY: 15

MONTH: May

YEAR: 2007

Regulation of Helicobacter pylori cagA expression in response to salt. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2984705

Regulation of Helicobacter pylori cagA expression in response to salt. Keywords Mesh Terms:

KEYWORDS: Up-Regulation

MESH TERMS: drug effects

Chemical & Substance for Abstract: Regulation of Helicobacter pylori cagA expression in response to salt. Information

Substance Name: Sodium Chloride

Registry Number: 7647-14-5

Grant and Affiliation Information for Regulation of Helicobacter pylori cagA expression in response to salt.

AFFILIATION: Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Country: United States

AGENCY: United States NIDDK

GRANT: R01 DK53623

ACRONYM: DK

MEDLINETA: Cancer Res

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