Regulation of heat shock-induced alterations in the release of prostaglandins by the uterine endometrium of cows.

Regulation of heat shock-induced alterations in the release of prostaglandins by the uterine endometrium of cows. Research Abstract Details 

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Regulation of heat shock-induced alterations in the release of prostaglandins by the uterine endometrium of cows. Abstract Text:

J R Malayer,P J Hansen,T S Gross,W W Thatcher,

Maternal heat stress in cattle may disrupt pregnancy by elevating uterine prostaglandin F(2alpha) (PGF(2alpha)) secretion. The objectives of this study were to determine the effects of elevated temperature (42 degrees C) in vitro upon 1) prostaglandin secretion by endometrial tissue; 2) the actions of extracellular regulators of uterine PGF [conceptus secretory proteins (bCSPs) and platelet-activating factor, (PAF)]; 3) the activity of the cyclooxygenase-endoperoxidase enzyme complex (PG synthetase); and 4) the activity of the endometrial PG synthesis inhibitor present in the endometrium from pregnant cattle. Endometrial explants at Day 17 of the estrous cycle produced more PGF than PGE(2) while elevated temperature caused increased PGF secretion but did not affect PGE(2) secretion. Elevated temperature did not reduce the ability of bCSPs or PAF to suppress release of PGF. The heat shock-induced increase in PGF at Day 17 was not due to the direct effects on PG synthetase, because PGF production from a cell-free cotyledonary microsomal enzyme preparation was reduced at elevated temperature. The activity of the cytosolic inhibitor of cyclooxygenase present in the endometrium of Day-17 pregnant cows could be reduced but not eliminated at 42 degrees C. We conclude that in vitro heat stress induces PGF secretion from the bovine uterine endometrium at Day 17 after estrus. This increase is not accompanied by the loss of regulatory capacity of conceptus products or increased activity of PG synthetase.

Regulation of heat shock-induced alterations in the release of prostaglandins by the uterine endometrium of cows. Publishing Authors By Initials

JR Malayer,PJ Hansen,TS Gross,WW Thatcher,

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Regulation of heat shock-induced alterations in the release of prostaglandins by the uterine endometrium of cows. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Theriogenology

VOLUME: 34

Page Numbers: 219-30

Journal Abbreviation: Theriogenology

ISSN: 0093-691X

DAY: 26

MONTH: Aug

YEAR: 1990

Regulation of heat shock-induced alterations in the release of prostaglandins by the uterine endometrium of cows. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Regulation of heat shock-induced alterations in the release of prostaglandins by the uterine endometrium of cows.

AFFILIATION: Dairy Science Department University of Florida, Gainesville, FL 32611-0701 USA.

Country: United States

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MEDLINETA: Theriogenology

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