Regulation of central melanocortin signaling by interleukin-1 beta.

Regulation of central melanocortin signaling by interleukin-1 beta. Research Abstract Details 

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Regulation of central melanocortin signaling by interleukin-1 beta. Abstract Text:

Jarrad M Scarlett,Erin E Jobst,Pablo J Enriori,Darren D Bowe,Ayesha K Batra,Wilmon F Grant,Michael A Cowley,Daniel L Marks,

Anorexia and involuntary weight loss are common and debilitating complications of a number of chronic diseases and inflammatory states. Proinflammatory cytokines, including IL-1 beta, are hypothesized to mediate these responses through direct actions on the central nervous system. However, the neural circuits through which proinflammatory cytokines regulate food intake and energy balance remain to be characterized. Here we report that IL-1 beta activates the central melanocortin system, a key neuronal circuit in the regulation of energy homeostasis. Proopiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus (ARC) were found to express the type I IL-1 receptor. Intracerebroventricular injection of IL-1 beta induced the expression of Fos protein in ARC POMC neurons but not in POMC neurons in the commissural nucleus of the tractus solitarius. We further show that IL-1 beta increases the frequency of action potentials of ARC POMC neurons and stimulates the release of alpha-MSH from hypothalamic explants in a dose-dependent fashion. Collectively, our data support a model in which IL-1 beta increases central melanocortin signaling by activating a subpopulation of hypothalamic POMC neurons and stimulating their release of alpha-MSH.

Regulation of central melanocortin signaling by interleukin-1 beta. Publishing Authors By Initials

JM Scarlett,EE Jobst,PJ Enriori,DD Bowe,AK Batra,WF Grant,MA Cowley,DL Marks,

For similar pathological conditions, signs and symptoms: signs and symptoms: body weight: body weight changes: weight loss research abstracts see: pathological conditions, signs and symptoms: signs and symptoms: body weight: body weight changes: weight loss research

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Regulation of central melanocortin signaling by interleukin-1 beta. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Endocrinology

VOLUME: 148

Page Numbers: 4217-25

Journal Abbreviation: Endocrinology

ISSN: 0013-7227

DAY: 24

MONTH: 05

YEAR: 2007

Regulation of central melanocortin signaling by interleukin-1 beta. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 375040

Regulation of central melanocortin signaling by interleukin-1 beta. Keywords Mesh Terms:

KEYWORDS: Weight Loss

MESH TERMS: physiology

Chemical & Substance for Abstract: Regulation of central melanocortin signaling by interleukin-1 beta. Information

Substance Name: Pro-Opiomelanocortin

Registry Number: 66796-54-1

Grant and Affiliation Information for Regulation of central melanocortin signaling by interleukin-1 beta.

AFFILIATION: Center for the Study of Weight Regulation and Associated Disorders, Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, Portland, Oregon 97239, USA.

Country: United States

AGENCY: United States NCRR

GRANT: RR00163

ACRONYM: RR

MEDLINETA: Endocrinology

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