Regulation of cell proliferation by interleukin-3-induced nuclear translocation of pyruvate kinase.

Regulation of cell proliferation by interleukin-3-induced nuclear translocation of pyruvate kinase. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Regulation of cell proliferation by interleukin-3-induced nuclear translocation of pyruvate kinase. Abstract Text:

Akemi Hoshino,John A Hirst,Hodaka Fujii,

Extracellular signaling molecules bound to cell surface receptors can regulate nuclear function with consequences for cell proliferation, differentiation, and function. To regulate nuclear function, signals must be transduced across the nuclear envelope to propagate the signal from the cytoplasm to the nucleus. Therefore, many signaling responses induce the nuclear translocation of transcription factors, kinases, and others. By using inducible translocation trap, a reporter gene-based system to detect inducible nuclear translocation, we found that the M2 isoform of pyruvate kinase, a key enzyme in glycolysis, translocates into the nucleus by interleukin-3, but not by epidermal growth factor, stimulation. The C domain of the M2 isoform of pyruvate kinase was sufficient for interleukin-3-induced nuclear translocation. Interleukin-3-induced nuclear translocation of the M2 isoform of pyruvate kinase was dependent on the activation of Jak2. Overexpression of the M2 isoform of pyruvate kinase protein fused with a nuclear localization signal enhanced cell proliferation in the absence of interleukin-3, suggesting that the nuclear pyruvate kinase plays an important role in cell proliferation.

Regulation of cell proliferation by interleukin-3-induced nuclear translocation of pyruvate kinase. Publishing Authors By Initials

A Hoshino,JA Hirst,H Fujii,

For similar biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research abstracts see: biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research

PUBMED ID PMID:

MEDLINE DATE:

Regulation of cell proliferation by interleukin-3-induced nuclear translocation of pyruvate kinase. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: The Journal of biological chemistry

VOLUME: 282

Page Numbers: 17706-11

Journal Abbreviation: J. Biol. Chem.

ISSN: 0021-9258

DAY: 19

MONTH: 04

YEAR: 2007

Regulation of cell proliferation by interleukin-3-induced nuclear translocation of pyruvate kinase. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985121

Regulation of cell proliferation by interleukin-3-induced nuclear translocation of pyruvate kinase. Keywords Mesh Terms:

KEYWORDS: Signal Transduction

MESH TERMS: physiology

Chemical & Substance for Abstract: Regulation of cell proliferation by interleukin-3-induced nuclear translocation of pyruvate kinase. Information

Substance Name: Pyruvate Kinase

Registry Number: EC 2.7.1.40

Grant and Affiliation Information for Regulation of cell proliferation by interleukin-3-induced nuclear translocation of pyruvate kinase.

AFFILIATION: Department of Pathology, New York University School of Medicine, New York, New York 10016, USA.

Country: United States

AGENCY: United States NIAID

GRANT: AI059315

ACRONYM: AI

MEDLINETA: J Biol Chem

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Regulation of cell proliferation by interleukin-3-induced nuclear translocation of pyruvate kinase Related Publications

• CCND1 messenger RNA expression is correlated with EGFR mutation status in lung cancer.
• Cell type-specific roles of Jak3 in IL-2-induced proliferative signal transduction.
• Characterization of neutral fragments issued from the photodissociation of protonated tryptophane.
• Comprehensive characterization of the photodissociation pathways of protonated tryptophan.
• Cooperation of NF-kappaB2/p100 activation and the PDZ domain binding motif signal in human T-cell leukemia virus type 1 (HTLV-1) Tax1 but not HTLV-2 Tax2 is crucial for interleukin-2-independent growth transformation of a T-cell line.
• Cross-presentation of glycolipid from tumor cells loaded with alpha-galactosylceramide leads to potent and long-lived T cell mediated immunity via dendritic cells.
• Development of multilocus single strand conformation polymorphism (MLSSCP) analysis of virulence genes of Listeria monocytogenes and comparison with existing DNA typing methods.
• Dissimilatory iodate reduction by marine Pseudomonas sp. strain SCT.
• Effects of BCAA Supplementation on Makers of Muscle Damage and Inflammation during Low-Intensity Prolonged Exercise: 2070: Board #140 May 31 3:30 PM 5:00 PM.
• Effects of smoking on odour identification in Japanese subjects.
• Expression of ECRG4 is an independent prognostic factor for poor survival in patients with esophageal squamous cell carcinoma.
• High prevalence of erythromycin resistance and macrolide-resistance genes, mefA and ermB, in Streptococcus pneumoniae isolates from the upper respiratory tracts of children in the Sapporo district, Japan.
• Hydrogen desorption mechanism in a Li-N-H system by means of the isotopic exchange technique.
• In situ observation of phase transformation in an Fe-Zn system at high temperatures using an image plate.
• Inactivation of tumor suppressor Dlg1 augments transformation of a T-cell line induced by human T-cell leukemia virus type 1 Tax protein.
• Isolation and characterization of mammalian D-aspartyl endopeptidase.
• Lacunar skull deformity and hydrocephalus in infants with myelomeningocele: is lacunar skull deformity a predictor of hydrocephalus development?
• Late intrathoracic relapse of pineal germinoma connected to intraspinal canal.
• Nras and Kras mutation in Japanese lung cancer patients: Genotyping analysis using LightCycler.
• Nuclear translocation of 2-amino-3-ketobutyrate coenzyme A ligase by cold and osmotic stress.
• PIK3CA gene amplification in Japanese non-small cell lung cancer.
• Phytoestrogens from Aspalathus linearis.
• Predictors of hepatic venous trunk invasion and prognostic factors in patients with hepatocellular carcinomas that had come into contact with the trunk of major hepatic veins.
• Primary malignant lymphoma of the cranial vault.
• Prognostic value of Ki-67 (MIB-1) and p53 in ependymomas.
• Ranitidine-induced drug eruption: another case of papuloerythroderma?
• Redundant promoter elements mediate IL-3-induced expression of a novel cytokine-inducible gene, cyclon.
• Regulation of cell proliferation by interleukin-3-induced nuclear translocation of pyruvate kinase.
• Secretin-stimulating MRCP in patients with pancreatobiliary maljunction and occult pancreatobiliary reflux: direct demonstration of pancreatobiliary reflux.
• Temporal regulation of Stat5 activity in determination of cell differentiation program.