[Regulation of c-myc expression in leukemic cell line Meg-01 by the death domain of Fas gene]

[Regulation of c-myc expression in leukemic cell line Meg-01 by the death domain of Fas gene] Research Abstract Details 

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[Regulation of c-myc expression in leukemic cell line Meg-01 by the death domain of Fas gene] Abstract Text:

H Liu,J Shan,S Tang,S Liu,

OBJECTIVE: To investigate the mechanism of disordered proliferation of leukemic cells and the proliferation inhibition by the Fas death domain (FASDD) in human leukemia cell line Meg-01. METHODS: The chimerical receptors (Fas/190, Fas/130) were constructed by Fas cytoplasmic domain with the leukemic inhibitory factor (LIF) receptor subunits gp190 and gp130, another chimerical receptor was constructed by replacing the gp130 in Fas/130 with Fas death domain (FAS/130f). The chimerical receptors were separately expressed on the membrane of Meg-01, and activated with anti-Fas antibodies to induce the oligomerics of the cytoplasmic regions (190cyt-190cyt-190cyt, 130cyt-130cyt-130cyt or FASDD-FASDD-FASDD) for initiating the intracellular signal transduction. c-myc expression level was assayed by means of immunoblotting and immunobiochemistry. RESULTS: Increased c-myc expression and cell proliferation were observed in the group of Fas/130 as compared with the other two groups. CONCLUSION: The cytoplasmic domain of gp130 might involve the induction of c-myc expression and the cell proliferation of Meg-01 cell. The Fas death domain may be a medium in the apoptosis induction against the effect of gp130.

[Regulation of c-myc expression in leukemic cell line Meg-01 by the death domain of Fas gene] Publishing Authors By Initials

H Liu,J Shan,S Tang,S Liu,

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[Regulation of c-myc expression in leukemic cell line Meg-01 by the death domain of Fas gene] Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zaz

VOLUME: 22

Page Numbers: 9-12

Journal Abbreviation: Zhonghua Xue Ye Xue Za Zhi

ISSN: 0253-2727

DAY: 5

MONTH: Jan

YEAR: 2001

[Regulation of c-myc expression in leukemic cell line Meg-01 by the death domain of Fas gene] Information

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LANGUAGE: chi

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AFFILIATION: Histology and Embryology Department, Second Military Medical University, Shanghai 200433, China.

Country: China

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MEDLINETA: Zhonghua Xue Ye Xue Za Zhi

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