Regulation of adipocyte differentiation of bone marrow stromal cells by transcription factor GATA-2.

Regulation of adipocyte differentiation of bone marrow stromal cells by transcription factor GATA-2. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Regulation of adipocyte differentiation of bone marrow stromal cells by transcription factor GATA-2. Abstract Text:

Yoko Okitsu,Shinichiro Takahashi,Naoko Minegishi,Junichi Kameoka,Mitsuo Kaku,Masayuki Yamamoto,Takeshi Sasaki,Hideo Harigae,Yoko Okitsu,Shinichiro Takahashi,Naoko Minegishi,Junichi Kameoka,Mitsuo Kaku,Masayuki Yamamoto,Takeshi Sasaki,Hideo Harigae,

GATA-2 is a transcription factor expressed in stem and progenitor cells of various cell lineages. In this study, we examined the role of GATA-2 in the differentiation of adipocytes, which are the main components of the microenvironment for hematopoiesis. Suppression of GATA-2 in TBR343, a preadipocytic stromal cell line, resulted in the acceleration of adipocyte differentiation. Conversely, overexpression of GATA-2 induced the resistance of adipocyte differentiation. In addition, regulatory elements of the GATA-2 gene in TBR343 are the same as those in hematopoietic cells. These results suggest that GATA-2 maintains a hematopoietic microenvironment by regulating the differentiation of adipocytes.

Regulation of adipocyte differentiation of bone marrow stromal cells by transcription factor GATA-2. Publishing Authors By Initials

Y Okitsu,S Takahashi,N Minegishi,J Kameoka,M Kaku,M Yamamoto,T Sasaki,H Harigae,Y Okitsu,S Takahashi,N Minegishi,J Kameoka,M Kaku,M Yamamoto,T Sasaki,H Harigae,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Regulation of adipocyte differentiation of bone marrow stromal cells by transcription factor GATA-2. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Biochemical and biophysical research communication

VOLUME: 364

Page Numbers: 383-7

Journal Abbreviation: Biochem. Biophys. Res. Commun.

ISSN: 1090-2104

DAY: 15

MONTH: 10

YEAR: 2007

Regulation of adipocyte differentiation of bone marrow stromal cells by transcription factor GATA-2. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 372516

Regulation of adipocyte differentiation of bone marrow stromal cells by transcription factor GATA-2. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Regulation of adipocyte differentiation of bone marrow stromal cells by transcription factor GATA-2. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Regulation of adipocyte differentiation of bone marrow stromal cells by transcription factor GATA-2.

AFFILIATION: Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Biochem Biophys Res Commun

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Regulation of adipocyte differentiation of bone marrow stromal cells by transcription factor GATA-2 Related Publications

• Interlaboratory comparison of quantitative rt-PCR based detection for minimal residual disease in leukemias: a standardization approach in Japan.
• Regulation of adipocyte differentiation of bone marrow stromal cells by transcription factor GATA-2.
• Reversible bone marrow dysplasia in patients with systemic lupus erythematosus.
• WorldSID Prototype Dummy Biomechanical Responses.
• [Anemia and iron metabolism]