Regulation of activated protein C by thrombin-modified protein S.

Regulation of activated protein C by thrombin-modified protein S. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Regulation of activated protein C by thrombin-modified protein S. Abstract Text:

K Suzuki,J Nishioka,S Hashimoto,

Protein S, a vitamin K-dependent plasma protein having Gla-residues, increases the rate of inactivation of Factor Va by activated protein C by enhancing the binding of activated protein C to phospholipid [Walker, J.F. (1981) J. Biol. Chem. 256, 11128-11131]. The present study aimed at elucidating the effect of thrombin-modified protein S on Factor Va inactivation by activated protein C. Nondigested protein S consisted 81% of intact form and 19% of modified form, and thrombin-digested protein S had 96% modified form. Protein S, both nondigested and digested, did not show any effects on the amidolytic activity of activated protein C towards synthetic peptide substrate. Nondigested protein S stimulated the Factor Va inactivation by activated protein C, whereas the digested protein appeared to suppress the inactivation. Protein-phospholipid binding experiments showed that although nondigested protein S enhanced the binding of activated protein C to phospholipid stoichiometrically, digested protein S appeared to not only suppress the complex formation, but also dissociate the complex. This evidence suggested that protein S modified by thrombin regulates the action of activated protein C towards Factor Va on phospholipid.

Regulation of activated protein C by thrombin-modified protein S. Publishing Authors By Initials

K Suzuki,J Nishioka,S Hashimoto,

For similar enzymes and coenzymes: enzymes: hydrolases: peptide hydrolases: endopeptidases: serine endopeptidases: thrombin research abstracts see: enzymes and coenzymes: enzymes: hydrolases: peptide hydrolases: endopeptidases: serine endopeptidases: thrombin research

PUBMED ID PMID:

MEDLINE DATE:

Regulation of activated protein C by thrombin-modified protein S. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of biochemistry

VOLUME: 94

Page Numbers: 699-705

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Sep

YEAR: 1983

Regulation of activated protein C by thrombin-modified protein S. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 376600

Regulation of activated protein C by thrombin-modified protein S. Keywords Mesh Terms:

KEYWORDS: Thrombin

MESH TERMS: metabolism

Chemical & Substance for Abstract: Regulation of activated protein C by thrombin-modified protein S. Information

Substance Name: Thrombin

Registry Number: EC 3.4.21.5

Grant and Affiliation Information for Regulation of activated protein C by thrombin-modified protein S.

AFFILIATION:

Country: JAPAN

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Biochem

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Regulation of activated protein C by thrombin-modified protein S Related Publications

• 3,3-diphenylpentane skeleton as a steroid skeleton substitute: novel inhibitors of human 5alpha-reductase 1.
• A novel neuronal cell line derived from the ventrolateral region of the suprachiasmatic nucleus.
• A short, formal, biomimetic synthesis of (+/-)-polygalolides A and B.
• Airflow produced by dielectric barrier discharge between asymmetric parallel rod electrodes.
• Bone morphogenetic protein-2 modulates Wnt and frizzled expression and enhances the canonical pathway of Wnt signaling in normal keratinocytes.
• Breakdown of atheromatous plaque due to shear force from arterial perfusion cannula.
• CXCL16 is a novel mediator of the innate immunity of epidermal keratinocytes.
• Cellular distribution of Mr 25,000 protein, a protein partially overlapping phosvitin and lipovitellin 2 in vitellogenin B1, and yolk proteins in Xenopus laevis oocytes and embryos.
• Central type 2 corticotropin-releasing hormone receptor mediates hypothalamic-pituitary-adrenocortical axis activation in the rat.
• Close association of centrosomes to the distal ends of the microbody during its growth, division and partitioning in the green alga Klebsormidium flaccidum.
• Co-activation of the secondary somatosensory and auditory cortices facilitates frequency discrimination of vibrotactile stimuli.
• Deciphering the disease process of schizophrenia: the contribution of cortical gaba neurons.
• Edaravone inhibits collagen-induced arthritis possibly through suppression of nuclear factor-kappa B.
• Effects of Immunomodulatory Derivatives of Thalidomide (IMiDs) and Their Analogs on Cell-Differentiation, Cyclooxygenase Activity and Angiogenesis.
• Estrogenic activity in sediments contaminated by nonylphenol in Tokyo Bay (Japan) evaluated by vitellogenin induction in male mummichogs (Fundulus heteroclitus).
• Experiment of seed germination with low pressure environment simulator.
• Generation of different fates from multipotent muscle stem cells.
• High occupancy of sigma-1 receptors in the human brain after single oral administration of fluvoxamine: a positron emission tomography study using [11C]SA4503.
• Impaired parathyroid hormone response to hypocalcemic stimuli in a patient with hypomagnesemic hypocalcemia.
• Interleukin-6 has differential influence on the ability of adjuvant formulations to potentiate antibody responses to a Plasmodium falciparum blood-stage vaccine.
• Nanoscale metal coordination macrocycles fabricated by using "dimeric" dipyrrins.
• Phospholipase A(2)-mediated superoxide production of murine peritoneal macrophages induced by chrysotile stimulation.
• Plasma levels of DJ-1 as a possible marker for progression of sporadic Parkinson's disease.
• Plasmodium falciparum anti-MSP1-19 antibodies induced by MSP1-42 and MSP1-19 based vaccines differed in specificity and parasite growth inhibition in terms of recognition of conserved versus variant epitopes.
• Pleural dissemination of thymoma showing tumor regression after combined corticosteroid and tacrolimus therapy.
• Recurrent p.N767S mutation in the ATP2A2 gene in a Japanese family with haemorrhagic Darier disease clinically mimicking epidermolysis bullosa simplex with mottled pigmentation.
• The change of plasma endothelin-1 levels before and after surgery with or without Down syndrome.
• Two alloalleles of Xenopus laevis hairy2 gene-evolution of duplicated gene function from a developmental perspective.
• [Development of new drugs targeting glial cells]
• [Stem cell systems in skeletal muscle]