Regulation of activated CD4+ T cells by NK cells via the Qa-1-NKG2A inhibitory pathway.

Regulation of activated CD4+ T cells by NK cells via the Qa-1-NKG2A inhibitory pathway. Research Abstract Details 

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Regulation of activated CD4+ T cells by NK cells via the Qa-1-NKG2A inhibitory pathway. Abstract Text:

Linrong Lu,Koichi Ikizawa,Dan Hu,Miriam B F Werneck,Kai W Wucherpfennig,Harvey Cantor,

The ability of natural-killer cells to regulate adaptive immunity is not well understood. Here we define an interaction between the class Ib major histocompatibility complex (MHC) molecule Qa-1-Qdm on activated T cells responsible for adaptive immunity and CD94-NKG2A inhibitory receptors expressed by natural-killer cells by using Qa-1-deficient and Qa-1 knockin mice containing a point mutation that selectively abolishes Qa-1-Qdm binding to CD94-NKG2A receptors. The Qa-1-NKG2A interaction protected activated CD4+ T cells from lysis by a subset of NKG2A+ NK cells and was essential for T cell expansion and development of immunologic memory. Antibody-dependent blockade of this Qa-1-NKG2A interaction resulted in potent NK-dependent elimination of activated autoreactive T cells and amelioration of experimental autoimmune encephalomyelitis. These findings extend the functional reach of the NK system to include regulation of adaptive T cell responses and suggest a new clinical strategy for elimination of antigen-activated T cells in the context of autoimmune disease and transplantation.

Regulation of activated CD4+ T cells by NK cells via the Qa-1-NKG2A inhibitory pathway. Publishing Authors By Initials

L Lu,K Ikizawa,D Hu,MB Werneck,KW Wucherpfennig,H Cantor,

For similar biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research abstracts see: biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research

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Regulation of activated CD4+ T cells by NK cells via the Qa-1-NKG2A inhibitory pathway. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Immunity

VOLUME: 26

Page Numbers: 593-604

Journal Abbreviation: Immunity

ISSN: 1074-7613

DAY: 3

MONTH: May

YEAR: 2007

Regulation of activated CD4+ T cells by NK cells via the Qa-1-NKG2A inhibitory pathway. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9432918

Regulation of activated CD4+ T cells by NK cells via the Qa-1-NKG2A inhibitory pathway. Keywords Mesh Terms:

KEYWORDS: Signal Transduction

MESH TERMS: immunology

Chemical & Substance for Abstract: Regulation of activated CD4+ T cells by NK cells via the Qa-1-NKG2A inhibitory pathway. Information

Substance Name: Interferon Type II

Registry Number: 82115-62-6

Grant and Affiliation Information for Regulation of activated CD4+ T cells by NK cells via the Qa-1-NKG2A inhibitory pathway.

AFFILIATION: Department of Cancer Immunology & AIDS, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA.

Country: United States

AGENCY: United States NIAID

GRANT: AI 37562

ACRONYM: AI

MEDLINETA: Immunity

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