Regulation and characterization of rot transcription in Staphylococcus aureus.

Regulation and characterization of rot transcription in Staphylococcus aureus. Research Abstract Details 

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Regulation and characterization of rot transcription in Staphylococcus aureus. Abstract Text:

Adhar C Manna,Binata Ray,

The pathogenesis of Staphylococcus aureus infections is dependent upon expression of various virulence factors, which are under the control of multiple regulatory systems, including two-component regulatory systems and transcriptional regulators such as the SarA family of proteins. As a part of a continuing effort to understand the regulatory mechanisms that involve the SarA protein family, the regulation and physical characterization of rot transcription is described here. The rot gene, a member of the sarA family of genes, was previously characterized and has been shown to regulate a large number of genes. The rot locus is composed of multiple overlapping transcripts as determined by primer extension and was proposed to encode an open reading frame of 133 residues. Transcription of rot was significantly increased in the sarA mutant. Gel shift and transcriptional studies revealed that SarA could bind to the rot promoter region, probably acting as a repressor for rot transcription. The data indicate that the expression of rot transcription is significantly repressed only by SarA among the sarA family of mutants tested at the post-exponential phase of growth.

Regulation and characterization of rot transcription in Staphylococcus aureus. Publishing Authors By Initials

AC Manna,B Ray,

For similar genetic processes: gene expression: transcription, genetic research abstracts see: genetic processes: gene expression: transcription, genetic research

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Regulation and characterization of rot transcription in Staphylococcus aureus. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Microbiology (Reading, England)

VOLUME: 153

Page Numbers: 1538-45

Journal Abbreviation:

ISSN: 1350-0872

DAY: 28

MONTH: May

YEAR: 2007

Regulation and characterization of rot transcription in Staphylococcus aureus. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9430468

Regulation and characterization of rot transcription in Staphylococcus aureus. Keywords Mesh Terms:

KEYWORDS: Transcription, Genetic

MESH TERMS: metabolism

Chemical & Substance for Abstract: Regulation and characterization of rot transcription in Staphylococcus aureus. Information

Substance Name: Green Fluorescent Proteins

Registry Number: 147336-22-9

Grant and Affiliation Information for Regulation and characterization of rot transcription in Staphylococcus aureus.

AFFILIATION: Division of Basic Biomedical Sciences, University of South Dakota, Vermillion, SD 57069, USA. amanna@usd.edu

Country: England

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MEDLINETA: Microbiology

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