Regulating regulatory T cells to achieve transplant tolerance.

Regulating regulatory T cells to achieve transplant tolerance. Research Abstract Details 

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Regulating regulatory T cells to achieve transplant tolerance. Abstract Text:

Ran Tao,Wayne W Hancock,

BACKGROUND: Regulatory T cells (Tregs) play crucial roles in both induction and maintenance of tolerance. This active immune regulation may contribute not only to the control of immune responses to self-antigens and thereby prevent autoimmune diseases, but also the control of responses to non-self molecules in adaptive immunity. Numerous experimental and clinical studies indicate that manipulating the balance between regulatory and responder T cells is an effective strategy to control immune responsiveness after transplantation. DATA SOURCES: Literature search was conducted using PubMed on the related subjects. Part of the material was based on the most recent work in the authors' laboratory. RESULTS: We propose some new strategies to achieve transplant tolerance in rodent animals via manipulating Treg function, including using histone deacetylase (HDAC) inhibitor to regulate Foxp3 transcription and enhance Treg suppression, induction of Treg-sparing apoptosis via Nur77, and identification of the co-inhibitory molecule herpes virus entry mediator (HVEM) as an effector molecule for Treg function. CONCLUSION: Regulation of Treg function will definitely provide us very promising tools to achieve clinical tolerance in the future.

Regulating regulatory T cells to achieve transplant tolerance. Publishing Authors By Initials

R Tao,WW Hancock,

For similar diagnosis: prognosis: treatment outcome research abstracts see: diagnosis: prognosis: treatment outcome research

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MEDLINE DATE:

Regulating regulatory T cells to achieve transplant tolerance. Journal Published:

PUBLICATION TYPE: Review

Journal: Hepatobiliary & pancreatic diseases international

VOLUME: 6

Page Numbers: 348-57

Journal Abbreviation: HBPD INT

ISSN: 1499-3872

DAY: 21

MONTH: Aug

YEAR: 2007

Regulating regulatory T cells to achieve transplant tolerance. Information

Number of References: 58

LANGUAGE: eng

NlmUniqueID: 101151457

Regulating regulatory T cells to achieve transplant tolerance. Keywords Mesh Terms:

KEYWORDS: Treatment Outcome

MESH TERMS: physiology

Chemical & Substance for Abstract: Regulating regulatory T cells to achieve transplant tolerance. Information

Substance Name: Histone Deacetylases

Registry Number: EC 3.5.1.-

Grant and Affiliation Information for Regulating regulatory T cells to achieve transplant tolerance.

AFFILIATION: Division of Transplantation Immunology, Department of Pathology and Laboratory Medicine, Joseph Stokes, Jr., Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA. taor@upmc.edu

Country: China

AGENCY: United States NIAID

GRANT: R01-AI 54720- 01

ACRONYM: AI

MEDLINETA: Hepatobiliary Pancreat Dis Int

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