Regular smoking and asthma incidence in adolescents.

Regular smoking and asthma incidence in adolescents. Research Abstract Details 

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Regular smoking and asthma incidence in adolescents. Abstract Text:

Frank D Gilliland,Talat Islam,Kiros Berhane,W James Gauderman,Rob McConnell,Edward Avol,John M Peters,

RATIONALE: Although involuntary exposure to maternal smoking during the in utero period and to secondhand smoke are associated with occurrence of childhood asthma, few studies have investigated the role of active cigarette smoking on asthma onset during adolescence. OBJECTIVES: To determine whether regular smoking is associated with the new onset of asthma during adolescence. METHODS: We conducted a prospective cohort study among 2,609 children with no lifetime history of asthma or wheezing who were recruited from fourth- and seventh-grade classrooms and followed annually in schools in 12 southern California communities. Regular smoking was defined as smoking at least seven cigarettes per day on average over the week before and 300 cigarettes in the year before each annual interview. Incident asthma was defined using new cases of physician-diagnosed asthma. MEASUREMENTS AND MAIN RESULTS: Regular smoking was associated with increased risk of new-onset asthma. Children who reported smoking 300 or more cigarettes per year had a relative risk (RR) of 3.9 (95% confidence interval [95% CI], 1.7-8.5) for new-onset asthma compared with nonsmokers. The increased risk from regular smoking was greater in nonallergic than in allergic children. Regular smokers who were exposed to maternal smoking during gestation had the largest risk from active smoking (RR, 8.8; 95% CI, 3.2-24.0). CONCLUSIONS: Regular smoking increased risk for asthma among adolescents, especially for nonallergic adolescents and those exposed to maternal smoking during the in utero period.

Regular smoking and asthma incidence in adolescents. Publishing Authors By Initials

FD Gilliland,T Islam,K Berhane,WJ Gauderman,R McConnell,E Avol,JM Peters,

For similar complex mixtures: particulate matter: smoke: tobacco smoke pollution research abstracts see: complex mixtures: particulate matter: smoke: tobacco smoke pollution research

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Regular smoking and asthma incidence in adolescents. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: American journal of respiratory and critical care

VOLUME: 174

Page Numbers: 1094-100

Journal Abbreviation: Am. J. Respir. Crit. Care Med.

ISSN: 1073-449X

DAY: 14

MONTH: 09

YEAR: 2006

Regular smoking and asthma incidence in adolescents. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9421642

Regular smoking and asthma incidence in adolescents. Keywords Mesh Terms:

KEYWORDS: Tobacco Smoke Pollution

MESH TERMS: physiopathology

Chemical & Substance for Abstract: Regular smoking and asthma incidence in adolescents. Information

Substance Name: Tobacco Smoke Pollution

Registry Number: 0

Grant and Affiliation Information for Regular smoking and asthma incidence in adolescents.

AFFILIATION: Department of Preventive Medicine, Keck School of Medicine of USC, 1540 Alcazar Street, CHP 236, Los Angeles, CA 90033, USA. gillilan@usc.edu

Country: United States

AGENCY: United States PHS

GRANT: RD831861-01

ACRONYM: HL

MEDLINETA: Am J Respir Crit Care Med

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