Regression of early and intermediate stages of colon cancer by targeting multiple members of the EGFR family with EGFR-related protein.

Regression of early and intermediate stages of colon cancer by targeting multiple members of the EGFR family with EGFR-related protein. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Regression of early and intermediate stages of colon cancer by targeting multiple members of the EGFR family with EGFR-related protein. Abstract Text:

Eva M Schmelz,Hu Xu,Radha Sengupta,Jianhua Du,Sanjeev Banerjee,Fazlul H Sarkar,Arun K Rishi,Adhip P N Majumdar,

A role of the epidermal growth factor receptor (EGFR) family has been suggested in colon cancer etiology, progression, and/or severity. Our recently identified pan-erbB inhibitor EGFR-related protein (ERRP) targets EGFRs by attenuating their activation and subsequent signaling leading to cellular growth inhibition. In the present study, we evaluated the therapeutic effectiveness of ERRP on early and intermediate stages of colon cancer by examining regression of chemically induced aberrant crypt foci (ACF) in the colon of CF1 mice and intestinal adenomas in APC(Min+/-) (Min) mice. After formation of ACF or adenomas, the mice were injected (i.p.) with ERRP (50 microg/mouse) for 10 consecutive days. This treatment significantly reduced the number of ACF from 25.0 +/- 3.0 (controls) to 14.9 +/- 1.6 (ERRP-treated; P = 0.011) and also reduced their size (P < 0.01). In Min mice, ERRP caused the regression of adenomas throughout the small intestine (P < 0.05) and reduced their size (P < 0.001). This could partly be attributed to inhibition of proliferation and stimulation of apoptosis in the intestinal mucosa and was associated with decreased activation of several EGFR family members, suppression of downstream effector nuclear factor kappaB and down-regulation of cyclooxygenase-2. ERRP-induced attenuation of EGFR activation could be due to increased sequestration of the ligand(s) by ERRP, rendering them unavailable for binding to and activation of the receptor. In conclusion, our data show that ERRP is effective in regressing both early and intermediate intestinal lesions and could be an effective therapeutic agent for colon cancer.

Regression of early and intermediate stages of colon cancer by targeting multiple members of the EGFR family with EGFR-related protein. Publishing Authors By Initials

EM Schmelz,H Xu,R Sengupta,J Du,S Banerjee,FH Sarkar,AK Rishi,AP Majumdar,

For similar peptides: intercellular signaling peptides and proteins: transforming growth factors: transforming growth factor alpha research abstracts see: peptides: intercellular signaling peptides and proteins: transforming growth factors: transforming growth factor alpha research

PUBMED ID PMID:

MEDLINE DATE:

Regression of early and intermediate stages of colon cancer by targeting multiple members of the EGFR family with EGFR-related protein. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Cancer research

VOLUME: 67

Page Numbers: 5389-96

Journal Abbreviation: Cancer Res.

ISSN: 0008-5472

DAY: 1

MONTH: Jun

YEAR: 2007

Regression of early and intermediate stages of colon cancer by targeting multiple members of the EGFR family with EGFR-related protein. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2984705

Regression of early and intermediate stages of colon cancer by targeting multiple members of the EGFR family with EGFR-related protein. Keywords Mesh Terms:

KEYWORDS: Transforming Growth Factor alpha

MESH TERMS: metabolism

Chemical & Substance for Abstract: Regression of early and intermediate stages of colon cancer by targeting multiple members of the EGFR family with EGFR-related protein. Information

Substance Name: Receptor, Epidermal Growth Factor

Registry Number: EC 2.7.1.112

Grant and Affiliation Information for Regression of early and intermediate stages of colon cancer by targeting multiple members of the EGFR family with EGFR-related protein.

AFFILIATION: Department of Nutrition and Food Science, Wayne State University, Detriot, Michigan 48220, USA.

Country: United States

AGENCY: United States NIA

GRANT: R01 AG014343

ACRONYM: AG

MEDLINETA: Cancer Res

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Regression of early and intermediate stages of colon cancer by targeting multiple members of the EGFR family with EGFR-related protein Related Publications

• A feasibility study of in vivo T1rho imaging of the intervertebral disc.
• A local adaptive threshold strategy for high resolution peripheral quantitative computed tomography of trabecular bone.
• A prospective and randomized study of radiotherapy, sequential chemotherapy radiotherapy and concomitant chemotherapy-radiotherapy in unresectable non small cell carcinoma of the lung.
• Automatic prospective registration of high-resolution trabecular bone images of the tibia.
• Biomedical evaluation of polyvinyl alcohol-gelatin esterified hydrogel for wound dressing.
• Characterization of trabecular bone structure from high-resolution magnetic resonance images using fuzzy logic.
• Combined image processing techniques for characterization of MRI cartilage of the knee.
• Comparison of Motion Encoding Waveforms for Magnetic Resonance Elastography at 3T.
• Curcumin enhances the effects of 5-fluorouracil and oxaliplatin in mediating growth inhibition of colon cancer cells by modulating EGFR and IGF-1R.
• Distinct effects of homogeneous weak disorder and dilute strong scatterers on phase competition in manganites.
• Emerging therapies in gastrointestinal cancers.
• Estrogen receptor beta1 and the beta2/betacx isoforms in nonneoplastic endometrium and in endometrioid carcinoma.
• Evaluation of fetal bone structure and mineralization in IGF-I deficient mice using synchrotron radiation microtomography and Fourier transform infrared spectroscopy.
• Experimental studies as an inspiration for clinical investigation.
• Fast magnetic resonance spectroscopic imaging at 3 Tesla using autocalibrating parallel technique.
• Fully balanced steady-state 3D-spin-echo (bSSSE) imaging at 3 Tesla.
• Immunoregulatory role of intestinal surfactant-like particles during Salmonella typhimurium infection.
• In vitro corneal permeation of diclofenac from oil drops.
• In vivo T(1rho) and T(2) mapping of articular cartilage in osteoarthritis of the knee using 3 T MRI.
• Induction of host protective Th1 immune response by chemokines in Leishmania donovani-infected BALB/c mice.
• Mechanisms of curcumin- and EGF-receptor related protein (ERRP)-dependent growth inhibition of colon cancer cells.
• Melting characteristics of highly supercoiled DNA.
• Parallel imaging of knee cartilage at 3 Tesla.
• Regression of early and intermediate stages of colon cancer by targeting multiple members of the EGFR family with EGFR-related protein.
• Regulation of gastrointestinal mucosal growth during aging.
• Single-shot fast spin-echo diffusion tensor imaging of the lumbar spine at 1.5 and 3 T.
• Statistics of the number of zero crossings: from random polynomials to the diffusion equation.
• The effects of geometric and threshold definitions on cortical bone metrics assessed by in vivo high-resolution peripheral quantitative computed tomography.
• Using a microcantilever array for detecting phase transitions and stability of DNA.
• Wavelet-based characterization of vertebral trabecular bone structure from magnetic resonance images at 3 T compared with micro-computed tomographic measurements.