Regionally specific cortical thinning and gray matter abnormalities in the healthy relatives of schizophrenia patients.

Regionally specific cortical thinning and gray matter abnormalities in the healthy relatives of schizophrenia patients. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Regionally specific cortical thinning and gray matter abnormalities in the healthy relatives of schizophrenia patients. Abstract Text:

Vina M Goghari,Kelly Rehm,Cameron S Carter,Angus W MacDonald,

Accumulated evidence suggests that schizophrenia is associated with subtle gray matter deficits throughout the cerebral cortex and regional cortical thinning. Although findings are not entirely consistent, healthy relatives of schizophrenia patients also show abnormalities in cortical gray matter volume, suggesting that this may be one aspect of an unexpressed genetic liability to the disorder. Cortical thickness and surface area are additional indicators of cortical cytoarchitectural integrity. To investigate the nature of cortical abnormalities in the healthy relatives of patients, this study used magnetic resonance imaging to evaluate gray matter volume, surface area, and thickness of 13 regions using an automated parcellation methodology. Compared with controls (n = 22), relatives (n = 19) had decreased volume and surface area in the right cingulate gyrus, a bilateral decrease in cingulate thickness, and decreased surface area in the superior temporal lobe. In addition, relatives had a subtle increase in gray matter volume and surface area in the left hemisphere, bilaterally in the parahippocampal gyri, and in the left middle temporal lobe. The results of this study suggest that the cortical regions most affected by the unexpressed genetic liability to schizophrenia may be the cingulate and temporal regions--regions associated with higher level cognitive, affective, and memory functions.

Regionally specific cortical thinning and gray matter abnormalities in the healthy relatives of schizophrenia patients. Publishing Authors By Initials

VM Goghari,K Rehm,CS Carter,AW MacDonald,

For similar mental disorders: schizophrenia and disorders with psychotic features: schizophrenia research abstracts see: mental disorders: schizophrenia and disorders with psychotic features: schizophrenia research

PUBMED ID PMID:

MEDLINE DATE:

Regionally specific cortical thinning and gray matter abnormalities in the healthy relatives of schizophrenia patients. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cerebral cortex (New York, N.Y. : 1991)

VOLUME: 17

Page Numbers: 415-24

Journal Abbreviation: Cereb. Cortex

ISSN: 1047-3211

DAY: 17

MONTH: 03

YEAR: 2006

Regionally specific cortical thinning and gray matter abnormalities in the healthy relatives of schizophrenia patients. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9110718

Regionally specific cortical thinning and gray matter abnormalities in the healthy relatives of schizophrenia patients. Keywords Mesh Terms:

KEYWORDS: Schizophrenia

MESH TERMS: pathology

Chemical & Substance for Abstract: Regionally specific cortical thinning and gray matter abnormalities in the healthy relatives of schizophrenia patients. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Regionally specific cortical thinning and gray matter abnormalities in the healthy relatives of schizophrenia patients.

AFFILIATION: Department of Psychology, University of Minnesota, Twin Cities, USA.

Country: United States

AGENCY: United States NIMH

GRANT: MH45156

ACRONYM: MH

MEDLINETA: Cereb Cortex

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Regionally specific cortical thinning and gray matter abnormalities in the healthy relatives of schizophrenia patients Related Publications

• A comparison of skinfold thickness, body mass index, bioelectrical impedance analysis and dual-energy X-ray absorptiometry in assessing body composition in obese subjects before and after weight loss.
• A late phase of Oskar accumulation is crucial for posterior patterning of the Drosophila embryo, and is blocked by ectopic expression of Bruno.
• Academic public health community responds to hurricanes: a history of the University of North Carolina School of Public Health response and new infrastructure, 1999-2006.
• Compliance with guidelines for emergency management of asthma in adults: experience at a tertiary care teaching hospital.
• Contribution of the remodeling response to cerebral vasospasm.
• Effects of temptations on the affective salience of weight control goals.
• Enhanced macroscopic desensitization shapes the response of alpha4 subtype-containing GABAA receptors to synaptic and extrasynaptic GABA.
• Evidence for 1,25-dihydroxyvitamin D3-independent transactivation by the vitamin D receptor: uncoupling the receptor and ligand in keratinocytes.
• Genetic criteria for Huntington's disease pathogenesis.
• Huntington's disease: seeing the pathogenic process through a genetic lens.
• Imp associates with squid and Hrp48 and contributes to localized expression of gurken in the oocyte.
• Is the drug court model exportable? The cost-effectiveness of a driving-under-the-influence court.
• Lipoplex formulation of superior efficacy exhibits high surface activity and fusogenicity, and readily releases DNA.
• Long-term EEG monitoring in the Neonatal Intensive Care Unit.
• Maternal mortality.
• Needs assessment and staff education to effect long-term change in emergency medicine in rural Nepal.
• Oskar controls morphology of polar granules and nuclear bodies in Drosophila.
• Predictors of cerebral infarction in patients with aneurysmal subarachnoid hemorrhage.
• Promiscuous females protect their offspring.
• Proton nuclear magnetic resonance spectroscopic determination of ethanol-induced formation of ethyl glucuronide in liver.
• Recovery and outcome of delirium in elderly medical inpatients.
• Regionally specific cortical thinning and gray matter abnormalities in the healthy relatives of schizophrenia patients.
• Synergistic potent insulin release by combinations of weak secretagogues in pancreatic islets and INS-1 cells.
• Synthesis and biological evaluation of phosphonate derivatives as autotaxin (ATX) inhibitors.
• The acute cardiovascular and metabolic responses to enteral and parenteral nutrition.
• The metabolic and cardiovascular effects of intravenous infusion of glucose or intralipid in normal humans.
• The relationship between ATP content and motility of bovine spermatozoa.
• Tracking and elucidating alphavirus-host protein interactions.
• Transfection activity of binary mixtures of cationic o-substituted phosphatidylcholine derivatives: the hydrophobic core strongly modulates physical properties and DNA delivery efficacy.
• Voltage-dependent calcium channels of dog basilar artery.