Regional multilineage differentiation potential of meniscal fibrochondrocytes: implications for meniscus repair.

Regional multilineage differentiation potential of meniscal fibrochondrocytes: implications for meniscus repair. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Regional multilineage differentiation potential of meniscal fibrochondrocytes: implications for meniscus repair. Abstract Text:

Robert L Mauck,Gabriel J Martinez-Diaz,Xiaoning Yuan,Rocky S Tuan,

The knee menisci are wedge-shaped semilunar fibrocartilaginous structures that reside between the femur and tibia and function to transmit and distribute load. These structures have characteristics of both fibrous and cartilaginous tissues. The cartilage-like inner region and the fibrous vascularized outer region each has a distinct extracellular matrix, and resident meniscal fibrochondrocytes (MFCs) with distinct morphologies dependent on their location. Damage to the meniscus is common, and disruption of tissue structure and function result in erosion of the underlying articular cartilage. It has been observed that damage in the vascular periphery undergoes spontaneous repair, whereas damage of the inner region does not heal. While vascularity of the peripheral region plays a role in healing, recent findings have also suggested that local cellular composition influences local healing capacity. This study examined the variation in multipotential characteristics of cell populations isolated from different regions of the bovine meniscus. MFCs were isolated from the outer (vascular), inner (avascular), and horn (mixed) regions and induced toward chondrogenic, adipogenic, and osteogenic lineages. The results of this study suggest that MFCs from all regions of the meniscus possess a multilineage differentiation capability, particularly toward chondrogenesis and adipogenesis. MFCs from the outer region were most plastic, differentiating along all three mesenchymal lineages. These findings may underlie the experimental observation of improved integration of meniscus grafts from the outer zone and may have implications for developing strategies of cell-based meniscus repair.

Regional multilineage differentiation potential of meniscal fibrochondrocytes: implications for meniscus repair. Publishing Authors By Initials

RL Mauck,GJ Martinez-Diaz,X Yuan,RS Tuan,

For similar biological phenomena, cell phenomena, and immunity: biological phenomena: regeneration research abstracts see: biological phenomena, cell phenomena, and immunity: biological phenomena: regeneration research

PUBMED ID PMID:

MEDLINE DATE:

Regional multilineage differentiation potential of meniscal fibrochondrocytes: implications for meniscus repair. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Intr

Journal: Anatomical record (Hoboken, N.J. : 2007)

VOLUME: 290

Page Numbers: 48-58

Journal Abbreviation:

ISSN: 1932-8486

DAY: 3

MONTH: Jan

YEAR: 2007

Regional multilineage differentiation potential of meniscal fibrochondrocytes: implications for meniscus repair. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101292775

Regional multilineage differentiation potential of meniscal fibrochondrocytes: implications for meniscus repair. Keywords Mesh Terms:

KEYWORDS: Regeneration

MESH TERMS: physiology

Chemical & Substance for Abstract: Regional multilineage differentiation potential of meniscal fibrochondrocytes: implications for meniscus repair. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Regional multilineage differentiation potential of meniscal fibrochondrocytes: implications for meniscus repair.

AFFILIATION: Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA.

Country: United States

AGENCY: United States NIAMS

GRANT: Z01 AR41113

ACRONYM: AR

MEDLINETA: Anat Rec (Hoboken)

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Regional multilineage differentiation potential of meniscal fibrochondrocytes: implications for meniscus repair Related Publications

• A facilitated tracking and transcription mechanism of long-range enhancer function.
• A second-generation autologous chondrocyte implantation approach to the treatment of focal articular cartilage defects.
• Activation of p38 and Smads mediates BMP-2 effects on human trabecular bone-derived osteoblasts.
• Biological response of chondrocytes cultured in three-dimensional nanofibrous poly(epsilon-caprolactone) scaffolds.
• Cell density dependent regulation of AP-1 activity is important for chondrogenic differentiation of C3H10T1/2 mesenchymal cells.
• Cellular signaling in developmental chondrogenesis: N-cadherin, Wnts, and BMP-2.
• Chondrogenic differentiation of murine C3H10T1/2 multipotential mesenchymal cells: I. Stimulation by bone morphogenetic protein-2 in high-density micromass cultures.
• Chondrogenic differentiation of murine C3H10T1/2 multipotential mesenchymal cells: II. Stimulation by bone morphogenetic protein-2 requires modulation of N-cadherin expression and function.
• Cross-talk between Wnt signaling pathways in human mesenchymal stem cells leads to functional antagonism during osteogenic differentiation.
• Depression status as a confounder in the effects of antidepressants on the gestation age.
• Fabrication and characterization of six electrospun poly(alpha-hydroxy ester)-based fibrous scaffolds for tissue engineering applications.
• Functional characterization of hypertrophy in chondrogenesis of human mesenchymal stem cells.
• Investigation of enablers of knowledge transfer in the medical industry.
• Mechanism of BMP-2 stimulated adhesion of osteoblastic cells to titanium alloy.
• Memory encoded throughout our bodies: molecular and cellular basis of tissue regeneration.
• Mesenchymal stem cell-based cartilage tissue engineering: cells, scaffold and biology.
• Mold-shaped, nanofiber scaffold-based cartilage engineering using human mesenchymal stem cells and bioreactor.
• Murine C3H10T1/2 multipotential cells as an in vitro model of mesenchymal chondrogenesis.
• Regional multilineage differentiation potential of meniscal fibrochondrocytes: implications for meniscus repair.
• Regulation of cartilaginous ECM gene transcription by chondrocytes and MSCs in 3D culture in response to dynamic loading.
• Repair of porcine articular cartilage defect with a biphasic osteochondral composite.
• Simulated joint infection assessment by rapid detection of live bacteria with real-time reverse transcription polymerase chain reaction.
• Spatiotemporal protein distribution of TGF-betas, their receptors, and extracellular matrix molecules during embryonic tendon development.
• TGF-beta1 calcium signaling in osteoblasts.
• Testing and estimation for variable single evoked brain potentials.
• Transforming growth factor-beta3 affects plasminogen activator inhibitor-1 expression in fetal mice and modulates fibroblast-mediated collagen gel contraction.
• Wnt signaling during BMP-2 stimulation of mesenchymal chondrogenesis.
• Wnt-3A enhances bone morphogenetic protein-2-mediated chondrogenesis of murine C3H10T1/2 mesenchymal cells.
• [30 Cases of pulmonary atelectasia during the course of acute broncho-pneumophathies in children.]
• [Primary cancer of the liver in a child 14 months old.]