Regional hemodynamics and oxygen supply during isovolemic hemodilution in the absence and presence of high-grade beta-adrenergic blockade.

Regional hemodynamics and oxygen supply during isovolemic hemodilution in the absence and presence of high-grade beta-adrenergic blockade. Research Abstract Details 

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Regional hemodynamics and oxygen supply during isovolemic hemodilution in the absence and presence of high-grade beta-adrenergic blockade. Abstract Text:

G J Crystal,J R Ruiz,M W Rooney,M R Salem,

Studies were performed in 16 pentobarbital-anesthetized dogs to evaluate regional circulatory effects of isovolemic hemodilution in the absence (group 1) and presence (group 2) of high-grade beta-adrenergic blockade with propranolol. Regional blood flow measured with 15 microm radioactive microspheres was used to calculate regional oxygen supply. In group 1, hemodilution with 5% dextran (40,000 molecular weight) reduced arterial hematocrit and oxygen content by approximately one half and had heterogeneous effects on regional blood flows. Blood flow was unchanged in the renal cortex, liver, and spleen, and it increased in the pancreas, duodenum, brain, and myocardium; however, only in the brain and myocardium were increases in blood flow sufficient to maintain oxygen supply at baseline (pre-hemodilution) levels. In group 2, intravenous administration of propranolol (1 mg/kg) itself decreased blood flow in the spleen and myocardium and had no other regional effects. Hemodilution after propranolol caused regional circulatory changes that were essentially similar to those in the absence of propranolol. It is concluded that (1) during isovolemic hemodilution, oxygen supply to the brain and myocardium is maintained at the expense of oxygen supply to less critical organs, and (2) this pattern of regional circulatory response during hemodilution remains intact in the presence of high-grade beta-adrenergic blockade with propranolol.

Regional hemodynamics and oxygen supply during isovolemic hemodilution in the absence and presence of high-grade beta-adrenergic blockade. Publishing Authors By Initials

GJ Crystal,JR Ruiz,MW Rooney,MR Salem,

For similar vasoconstriction research abstracts see: vasoconstriction research

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Regional hemodynamics and oxygen supply during isovolemic hemodilution in the absence and presence of high-grade beta-adrenergic blockade. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of cardiothoracic anesthesia

VOLUME: 2

Page Numbers: 772-9

Journal Abbreviation:

ISSN: 0888-6296

DAY: 3

MONTH: Dec

YEAR: 1988

Regional hemodynamics and oxygen supply during isovolemic hemodilution in the absence and presence of high-grade beta-adrenergic blockade. Information

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LANGUAGE: eng

NlmUniqueID: 8709732

Regional hemodynamics and oxygen supply during isovolemic hemodilution in the absence and presence of high-grade beta-adrenergic blockade. Keywords Mesh Terms:

KEYWORDS: Vasoconstriction

MESH TERMS: drug effects

Chemical & Substance for Abstract: Regional hemodynamics and oxygen supply during isovolemic hemodilution in the absence and presence of high-grade beta-adrenergic blockade. Information

Substance Name: Oxygen

Registry Number: 7782-44-7

Grant and Affiliation Information for Regional hemodynamics and oxygen supply during isovolemic hemodilution in the absence and presence of high-grade beta-adrenergic blockade.

AFFILIATION: Department of Anesthesiology, Illinois Masonic Medical Center, 836 W Wellington Ave, Chicago, IL 60657, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: HL-33803

ACRONYM: HL

MEDLINETA: J Cardiothorac Anesth

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