Regional control of chromatin organization by noncoding roX RNAs and the NURF remodeling complex in Drosophila melanogaster.

Regional control of chromatin organization by noncoding roX RNAs and the NURF remodeling complex in Drosophila melanogaster. Research Abstract Details 

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Regional control of chromatin organization by noncoding roX RNAs and the NURF remodeling complex in Drosophila melanogaster. Abstract Text:

X Bai,E Larschan,S Y Kwon,P Badenhorst,M I Kuroda,

Dosage compensation in Drosophila is mediated by a histone-modifying complex that upregulates transcription of genes on the single male X chromosome. The male-specific lethal (MSL) complex contains at least five proteins and two noncoding roX (RNA on X) RNAs. The mechanism by which the MSL complex targets the X chromosome is not understood. Here we use a sensitized system to examine the function of roX genes on the X chromosome. In mutants that lack the NURF nucleosome remodeling complex, the male polytene X chromosome is severely distorted, appearing decondensed. This aberrant morphology is dependent on the MSL complex. Strikingly, roX mutations suppress the Nurf mutant phenotype regionally on the male X chromosome. Furthermore, a roX transgene induces disruption of local flanking autosomal chromatin in Nurf mutants. Taken together, these results demonstrate the potent capability of roX genes to organize large chromatin domains in cis, on the X chromosome. In addition to interacting functions at the level of chromosome morphology, we also find that NURF complex and MSL proteins have opposing effects on roX RNA transcription. Together, these results demonstrate the importance of a local balance between modifying activities that promote and antagonize chromatin compaction within defined chromatin domains in higher organisms.

Regional control of chromatin organization by noncoding roX RNAs and the NURF remodeling complex in Drosophila melanogaster. Publishing Authors By Initials

X Bai,E Larschan,SY Kwon,P Badenhorst,MI Kuroda,

For similar cells: cellular structures: chromosomes: sex chromosomes: x chromosome research abstracts see: cells: cellular structures: chromosomes: sex chromosomes: x chromosome research

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Regional control of chromatin organization by noncoding roX RNAs and the NURF remodeling complex in Drosophila melanogaster. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Genetics

VOLUME: 176

Page Numbers: 1491-9

Journal Abbreviation: Genetics

ISSN: 0016-6731

DAY: 16

MONTH: 05

YEAR: 2007

Regional control of chromatin organization by noncoding roX RNAs and the NURF remodeling complex in Drosophila melanogaster. Information

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LANGUAGE: eng

NlmUniqueID: 374636

Regional control of chromatin organization by noncoding roX RNAs and the NURF remodeling complex in Drosophila melanogaster. Keywords Mesh Terms:

KEYWORDS: X Chromosome

MESH TERMS: genetics

Chemical & Substance for Abstract: Regional control of chromatin organization by noncoding roX RNAs and the NURF remodeling complex in Drosophila melanogaster. Information

Substance Name: roX1 protein, Drosophila

Registry Number: 0

Grant and Affiliation Information for Regional control of chromatin organization by noncoding roX RNAs and the NURF remodeling complex in Drosophila melanogaster.

AFFILIATION: Howard Hughes Medical Institute, Harvard-Partners Center for Genetics and Genomics, Brigham and Women's Hospital, Boston, Massachusetts, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM45744

ACRONYM: GM

MEDLINETA: Genetics

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