Regional changes in bone mineral density following spinal cord injury in children.

Regional changes in bone mineral density following spinal cord injury in children. Research Abstract Details 

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Regional changes in bone mineral density following spinal cord injury in children. Abstract Text:

Anthony J W Liu,Julie N Briody,Craig F Munns,Mary-Clare A Waugh,

Objective: To document the serial changes in bone mineral density (BMD) following paediatric spinal cord injury (SCI). Design: Retrospective case series. Setting: Paediatric tertiary care hospital. Patients: Eighteen children (nine males) followed in an outpatient spinal cord injury service. Interventions: Not applicable. Main outcome measure: Serial bone mineral density (BMD) measurements using dual energy X-ray absorptiometry (DXA). Results: Mean follow-up was 5.0 +/- 3.6 years (range 0.4-12.4 years). Three children sustained minimal trauma fractures, all femoral. For the cohort, BMD Z-scores were significantly less than zero in the legs (-2.7 +/- 2.0, p < 0.001), femoral neck (-2.1 +/- 1.4, p < 0.001), total body (-0.8 +/- 1.3, p = 0.02) and lumbar spine (-0.8 +/- 1.6, p = 0.04), but not in the arms (-0.2 +/- 1.0, p = 0.5). Lean tissue mass (LTM) Z-scores were reduced in the legs (-1.9 +/- 1.3, p < 0.001). Longitudinal data showed an initial decline in lower extremity BMD, BMC and LTM aged-matched Z-scores in the 12 months following SCI, followed by an age appropriate increase thereafter. Conclusions: Lower extremity osteopenia and sarcopenia develop rapidly in the first 12 months following the SCI. The reduced bone strength increases the risk of low trauma fracture.

Regional changes in bone mineral density following spinal cord injury in children. Publishing Authors By Initials

AJ Liu,JN Briody,CF Munns,MC Waugh,

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MEDLINE DATE: 2008 Jan-Mar

Regional changes in bone mineral density following spinal cord injury in children. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Developmental neurorehabilitation

VOLUME: 11

Page Numbers: 51-9

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ISSN: 1751-8423

DAY: 21

MONTH: 12

YEAR: 2007

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LANGUAGE: eng

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Grant and Affiliation Information for Regional changes in bone mineral density following spinal cord injury in children.

AFFILIATION: Department of Paediatrics, Nepean Hospital, Nepean Clinical School, University of Sydney, New South Wales, Australia.

Country: England

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MEDLINETA: Dev Neurorehabil

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