Regional cerebral perfusion abnormalities in developmental language disorder : Statistical parametric mapping analysis.

Regional cerebral perfusion abnormalities in developmental language disorder : Statistical parametric mapping analysis. Research Abstract Details 

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Regional cerebral perfusion abnormalities in developmental language disorder : Statistical parametric mapping analysis. Abstract Text:

J W Hwang,J-B Lee,B-N Kim,H-Y Lee,D-S Lee,M-S Shin,S-C Cho,Jun Won Hwang,Jeong-Bum Lee,Boong-Nyun Kim,Ho-Young Lee,Dong-Soo Lee,Min-Sup Shin,Soo-Churl Cho,Jun Won Hwang,Jeong-Bum Lee,Boong-Nyun Kim,Ho-Young Lee,Dong-Soo Lee,Min-Sup Shin,Soo-Churl Cho,

OBJECTIVE: A voxel based investigation of cerebral blood flow was conducted to identify brain functional differences during resting state between children with developmental language disorder (DLD) and normal controls.METHOD: Using DSM-IV criteria, we selected 21 children with DLD.All children were examined by technetium-99m-HMPAO Brain SPECT. Using SPM analyses, we compared the SPECT images of children with DLD and those of 17 control subjects on a voxel by voxel basis using ANCOVA covarying for age.RESULTS: Reduced cerebral blood flow in the right putamen,the right inferior parietal cortex, and the left globus pallidus were found in children with DLD versus the controls. However, no area of increased cerebral blood flow was observed in children with DLD compared to the controls.CONCLUSION: Though results should be interpreted cautiously, this study confirms the presence of functional defects in the basal ganglia and the inferior parietal lobe during the resting state of the brains of children with DLD. It also gives further evidence for functional deficits in basal ganglia as an important factor in the etiology of DLD.

Regional cerebral perfusion abnormalities in developmental language disorder : Statistical parametric mapping analysis. Publishing Authors By Initials

JW Hwang,JB Lee,BN Kim,HY Lee,DS Lee,MS Shin,SC Cho,JW Hwang,JB Lee,BN Kim,HY Lee,DS Lee,MS Shin,SC Cho,JW Hwang,JB Lee,BN Kim,HY Lee,DS Lee,MS Shin,SC Cho,

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Regional cerebral perfusion abnormalities in developmental language disorder : Statistical parametric mapping analysis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: European archives of psychiatry and clinical neuro

VOLUME: 256

Page Numbers: 131-7

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ISSN: 0940-1334

DAY: 20

MONTH: 04

YEAR: 2006

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LANGUAGE: eng

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AFFILIATION: Division of Child & Adolescent Psychiatry, Department of Neuropsychiatry, Seoul National University Hospital, 28 Yungundong, Chongnogu, Seoul, Korea, soochurl@snu.ac.kr.

Country: Germany

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MEDLINETA: Eur Arch Psychiatry Clin Neuro

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