Regional cerebral blood flow study with 123I-IMP in patients with degenerative dementia.

Regional cerebral blood flow study with 123I-IMP in patients with degenerative dementia. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Regional cerebral blood flow study with 123I-IMP in patients with degenerative dementia. Abstract Text:

T Ohnishi,H Hoshi,S Nagamachi,S Jinnouchi,S Futami,K Watanabe,Y Mitsuyama,

Regional cerebral blood flow was evaluated by single-photon emission CT (SPECT) with 123I-N-isopropyl-p-iodoamphetamine (123I-IMP) in 11 patients with dementia of the Alzheimer type, three patients with progressive dementia and motor neuron disease, and eight healthy control subjects. Regional blood flow measurements in the bilateral frontal, parietal association, and temporal cortices were lower in the Alzheimer dementia patients than in controls. Flow deficits in the parietal association cortex were demonstrated in all patients with Alzheimer-type dementia; these deficits were correlated with the severity of disease. Lateral hemispheric asymmetry was seen in nine of 11 patients with Alzheimer-type dementia. In all three patients with progressive dementia and motor neuron disease, flow deficits were demonstrated in the bilateral frontal and temporal cortices, but no flow deficits were seen in the parietal association cortex. Brain SPECT with 123I-IMP may be useful in the differential diagnosis and evaluation of the severity of degenerative dementia.

Regional cerebral blood flow study with 123I-IMP in patients with degenerative dementia. Publishing Authors By Initials

T Ohnishi,H Hoshi,S Nagamachi,S Jinnouchi,S Futami,K Watanabe,Y Mitsuyama,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Regional cerebral blood flow study with 123I-IMP in patients with degenerative dementia. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: AJNR. American journal of neuroradiology

VOLUME: 12

Page Numbers: 513-20

Journal Abbreviation:

ISSN: 0195-6108

DAY: 14

MONTH: 02

YEAR: 2008

Regional cerebral blood flow study with 123I-IMP in patients with degenerative dementia. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8003708

Regional cerebral blood flow study with 123I-IMP in patients with degenerative dementia. Keywords Mesh Terms:

KEYWORDS: Tomography, Emission-Computed, Single-Ph

MESH TERMS: radionuclide imaging

Chemical & Substance for Abstract: Regional cerebral blood flow study with 123I-IMP in patients with degenerative dementia. Information

Substance Name: Iofetamine

Registry Number: 95896-48-3

Grant and Affiliation Information for Regional cerebral blood flow study with 123I-IMP in patients with degenerative dementia.

AFFILIATION: Department of Radiology, Miyazaki Medical College, Japan.

Country: UNITED STATES

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: AJNR Am J Neuroradiol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Regional cerebral blood flow study with 123I-IMP in patients with degenerative dementia Related Publications

• Critical involvement of pneumolysin in production of interleukin-1alpha and caspase-1-dependent cytokines in infection with Streptococcus pneumoniae in vitro: a novel function of pneumolysin in caspase-1 activation.
• Dementia with motor neuron disease.
• Dependency of Caspase-1 Activation Induced in Macrophages by Listeria monocytogenes on Cytolysin, Listeriolysin O, after Evasion from Phagosome into the Cytoplasm.
• Glutamate excess and free radical formation during and following kainic acid-induced status epilepticus.
• Irreversible loss of membrane-binding activity of Listeria-derived cytolysins in non-acidic conditions: a distinct difference from allied cytolysins produced by other Gram-positive bacteria.
• Measurement of laminins in the cerebrospinal fluid obtained from patients with Alzheimer's disease and vascular dementia using a modified enzyme-linked immunosorbent assay.
• New Computer-based Cognitive Function Test for the Elderly.
• RD1 region in mycobacterial genome is involved in the induction of necrosis in infected RAW264 cells via mitochondrial membrane damage and ATP depletion.
• Regional cerebral blood flow study with 123I-IMP in patients with degenerative dementia.
• Serum protein binding kinetics of phenytoin in monotherapy patients.
• [Basis of quinolone antibiotics]
• [Molecular mechanism of host response to bacterial infection]