Regional cerebral blood flow and blood volume in patients with subcortical arteriosclerotic encephalopathy (SAE).

Regional cerebral blood flow and blood volume in patients with subcortical arteriosclerotic encephalopathy (SAE). Research Abstract Details 

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Regional cerebral blood flow and blood volume in patients with subcortical arteriosclerotic encephalopathy (SAE). Abstract Text:

Friedemann J ,Gunnar Brix,Michael Hennerici,Robert Lucht,Christine ,Wolfgang Neff,

The aim of the present study was a detailed analysis of the regional cerebral blood flow and blood volume in patients with subcortical arteriosclerotic encephalopathy (SAE) by means of functional magnetic resonance imaging (MRI). A group of 26 patients with SAE and a group of 16 age-matched healthy volunteers were examined. Using a well-established dynamic susceptibility contrast-enhanced MRI method, the regional cerebral blood flow (rCBF) and blood volume (rCBV) were quantified for each subject in 12 different regions in the brain parenchyma. As compared to healthy volunteers, patients with SAE showed significantly reduced rCBF and rCBV values in white matter regions and in the occipital cortex. Regions containing predominantly grey matter show almost normal rCBF and rCBV values. In conclusion, quantitative analysis of rCBF and rCBV values demonstrates clearly that SAE is a disease that is associated with a reduced microcirculation predominantly in white matter.

Regional cerebral blood flow and blood volume in patients with subcortical arteriosclerotic encephalopathy (SAE). Publishing Authors By Initials

FJ ,G Brix,M Hennerici,R Lucht,C ,W Neff,

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Regional cerebral blood flow and blood volume in patients with subcortical arteriosclerotic encephalopathy (SAE). Journal Published:

PUBLICATION TYPE: Journal Article

Journal: European radiology

VOLUME: 17

Page Numbers: 2483-90

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ISSN: 0938-7994

DAY: 6

MONTH: 03

YEAR: 2007

Regional cerebral blood flow and blood volume in patients with subcortical arteriosclerotic encephalopathy (SAE). Information

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LANGUAGE: eng

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AFFILIATION: Institut für Klinische Radiologie, Universitätsklinik Mannheim, der Universität Heidelberg, Lauertstr 23, D-69242, Mühlhausen, Germany. friedjmgue@t-online.de

Country: Germany

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MEDLINETA: Eur Radiol

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