Regional brain variations of cytochrome oxidase activity in spontaneously hypertensive mice.

Regional brain variations of cytochrome oxidase activity in spontaneously hypertensive mice. Research Abstract Details 

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Regional brain variations of cytochrome oxidase activity in spontaneously hypertensive mice. Abstract Text:

C Strazielle,R Lalonde,S Thifault,P Hamet,

To explore the central disturbances resulting from blood pressure changes, spontaneously hypertensive mice (SHM) were compared to normotensive controls for cytochrome oxidase (CO) activity, an index of oxidative capacity in the central nervous system and a marker of long-term regional brain metabolism and neuronal activity. In all brain areas presenting significant enzymatic variations, only increases in CO activity were found in SHM, particularly the central autonomic network. However, only specific regions were affected, namely the insular cortex and the hypothalamic nuclei principally involved in high-order autonomic control. Altered limbic structures included the lateral septum, various hippocampal subregions, as well as prelimbic cortex. CO activity was also elevated in several forebrain regions, including those directly connected to the limbic system, such as the nucleus accumbens, the claustrum, and dorsomedial and reticular thalamic nuclei, as well as subthalamic and ventrolateral thalamic nuclei. In the brainstem, the only regions affected were the locus coeruleus, site of noradrenergic cell bodies, the trigeminal system, and four interconnected regions: the inferior colliculus, the paramedial reticular formation, the medial vestibular, and the cerebellar fastigial nuclei. These data show that specific regions modulating sympathetic nerve discharge are activated in young adult SHM, possibly due to mitochondrial dysfunction and excitotoxicity.

Regional brain variations of cytochrome oxidase activity in spontaneously hypertensive mice. Publishing Authors By Initials

C Strazielle,R Lalonde,S Thifault,P Hamet,

For similar nervous system: nerve net research abstracts see: nervous system: nerve net research

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Regional brain variations of cytochrome oxidase activity in spontaneously hypertensive mice. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Experimental brain research. Experimentelle Hirnfo

VOLUME: 157

Page Numbers: 255-64

Journal Abbreviation:

ISSN: 0014-4819

DAY: 6

MONTH: 03

YEAR: 2004

Regional brain variations of cytochrome oxidase activity in spontaneously hypertensive mice. Information

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LANGUAGE: eng

NlmUniqueID: 43312

Regional brain variations of cytochrome oxidase activity in spontaneously hypertensive mice. Keywords Mesh Terms:

KEYWORDS: Nerve Net

MESH TERMS: enzymology

Chemical & Substance for Abstract: Regional brain variations of cytochrome oxidase activity in spontaneously hypertensive mice. Information

Substance Name: Electron Transport Complex IV

Registry Number: EC 1.9.3.1

Grant and Affiliation Information for Regional brain variations of cytochrome oxidase activity in spontaneously hypertensive mice.

AFFILIATION: Université Henri Poincaré, EMI-INSERM 0014 and Service de Microscopie Electronique, 54500 Vandoeuvre-les-Nancy, France. straziel@persmail.uhp-nancy.fr

Country: Germany

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MEDLINETA: Exp Brain Res

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