Regenerative medicine in orthopaedic surgery.

Regenerative medicine in orthopaedic surgery. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Regenerative medicine in orthopaedic surgery. Abstract Text:

Karin A Corsi,Edward M Schwarz,David J Mooney,Johnny Huard,

Regenerative medicine holds great promise for orthopaedic surgery. As surgeons continue to face challenges regarding the healing of diseased or injured musculoskeletal tissues, regenerative medicine aims to develop novel therapies that will replace, repair, or promote tissue regeneration. This review article will provide an overview of the different research areas involved in regenerative medicine, such as stem cells, bioinductive factors, and scaffolds. The potential use of stem cells for orthopaedic tissue engineering will be addressed by presenting the current progress with skeletal muscle-derived stem cells. As well, the development of a revascularized massive allograft will be described and will serve as a prototypic model of orthopaedic tissue engineering. Lastly, we will describe current approaches used to design cell instructive materials and how they can be used to promote and regulate the formation of bony tissue.

Regenerative medicine in orthopaedic surgery. Publishing Authors By Initials

KA Corsi,EM Schwarz,DJ Mooney,J Huard,

For similar investigative techniques: clinical laboratory techniques: culture techniques: tissue engineering research abstracts see: investigative techniques: clinical laboratory techniques: culture techniques: tissue engineering research

PUBMED ID PMID:

MEDLINE DATE:

Regenerative medicine in orthopaedic surgery. Journal Published:

PUBLICATION TYPE: Review

Journal: Journal of orthopaedic research : official publica

VOLUME: 25

Page Numbers: 1261-8

Journal Abbreviation: J. Orthop. Res.

ISSN: 0736-0266

DAY: 3

MONTH: Oct

YEAR: 2007

Regenerative medicine in orthopaedic surgery. Information

Number of References: 71

LANGUAGE: eng

NlmUniqueID: 8404726

Regenerative medicine in orthopaedic surgery. Keywords Mesh Terms:

KEYWORDS: Tissue Engineering

MESH TERMS: methods

Chemical & Substance for Abstract: Regenerative medicine in orthopaedic surgery. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Regenerative medicine in orthopaedic surgery.

AFFILIATION: Stem Cell Research Center, Children's Hospital of Pittsburgh, 4100 Rangos Research Center, 3460 Fifth Avenue, Pittsburgh, Pennsylvania 15213, USA.

Country: United States

AGENCY: United States NIAMS

GRANT: AR51469

ACRONYM: AR

MEDLINETA: J Orthop Res

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Regenerative medicine in orthopaedic surgery Related Publications

• A relationship between vascular endothelial growth factor, angiogenesis, and cardiac repair after muscle stem cell transplantation into ischemic hearts.
• A role for cell sex in stem cell-mediated skeletal muscle regeneration: female cells have higher muscle regeneration efficiency.
• Adenovirus-mediated direct gene therapy with bone morphogenetic protein-2 produces bone.
• Clonal isolation of muscle-derived cells capable of enhancing muscle regeneration and bone healing.
• Decorin gene transfer promotes muscle cell differentiation and muscle regeneration.
• Dominant negative Bmp5 mutation reveals key role of BMPs in skeletal response to mechanical stimulation.
• Effect of bone morphogenetic protein-2-expressing muscle-derived cells on healing of critical-sized bone defects in mice.
• Enhancement of bone healing based on ex vivo gene therapy using human muscle-derived cells expressing bone morphogenetic protein 2.
• Ex vivo gene therapy to produce bone using different cell types.
• Growth factors improve muscle healing in vivo.
• Human skeletal muscle cells in ex vivo gene therapy to deliver bone morphogenetic protein-2.
• Interaction between macrophages, TGF-beta1, and the COX-2 pathway during the inflammatory phase of skeletal muscle healing after injury.
• Malignant transformation of multipotent muscle-derived cells by concurrent differentiation signals.
• Muscle-based gene therapy and tissue engineering.
• Muscle-derived stem cells for tissue engineering and regenerative therapy.
• Osteogenic potential of postnatal skeletal muscle-derived stem cells is influenced by donor sex.
• Osteoprogenitor cells within skeletal muscle.
• Regenerative Medicine for the Musculoskeletal System Based on Muscle-derived Stem Cells.
• Regenerative medicine in orthopaedic surgery.
• Report of case of Löffler's syndrome with a concomitant nonspecific maculo-papular rash.
• Sex differences in muscle-derived stem cells and skeletal muscle.
• Skeletal muscle fiber type conversion during the repair of mouse soleus: potential implications for muscle healing after injury.
• The effect of bone morphogenetic protein-2 expression on the early fate of skeletal muscle-derived cells.
• The efficiency of muscle-derived cell-mediated bone formation.
• [Cellular therapy can be affected by the sex of the stem cell used]
• [Not Available.]
• [Not Available.]
• [Not Available.]
• [Not Available.]
• [Not Available.]