Regenerative Medicine for the Musculoskeletal System Based on Muscle-derived Stem Cells.

Regenerative Medicine for the Musculoskeletal System Based on Muscle-derived Stem Cells. Research Abstract Details 

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Regenerative Medicine for the Musculoskeletal System Based on Muscle-derived Stem Cells. Abstract Text:

Charley B Gates,Tharun Karthikeyan,Freddie Fu,Johnny Huard,

The identification and characterization of stem cells is introducing a paradigm shift in the field of orthopaedic surgery. Whereas in the past, diseased tissue was replaced with allograft material, current trends in research revolve around regenerating damaged tissue. Muscle-derived stem cells have an application in regeneration of articular cartilage, bone, and skeletal muscle. These postnatal (ie, adult) stem cells can be readily isolated via muscle biopsy. They can display long-term proliferation, high self-renewal, and multipotent differentiation. They also can be genetically modified to secrete growth factors important to tissue healing, thereby functioning as implantable, long-lasting reservoirs for these molecules. Taken together, this evidence suggests that muscle-derived stem cells are well suited for gene therapy and tissue engineering applications for the musculoskeletal system. Effective implementation of even just a few applications of muscle-derived stem cell-based tissue engineering has the potential to revolutionize the way certain musculoskeletal diseases are managed.

Regenerative Medicine for the Musculoskeletal System Based on Muscle-derived Stem Cells. Publishing Authors By Initials

CB Gates,T Karthikeyan,F Fu,J Huard,

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Regenerative Medicine for the Musculoskeletal System Based on Muscle-derived Stem Cells. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Journal of the American Academy of Orthopaedic

VOLUME: 16

Page Numbers: 68-76

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ISSN: 1067-151X

DAY: 6

MONTH: Feb

YEAR: 2008

Regenerative Medicine for the Musculoskeletal System Based on Muscle-derived Stem Cells. Information

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LANGUAGE: eng

NlmUniqueID: 9417468

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Country: United States

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MEDLINETA: J Am Acad Orthop Surg

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