Regeneration of mastoid air cells: clinical applications.

Regeneration of mastoid air cells: clinical applications. Research Abstract Details 

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Regeneration of mastoid air cells: clinical applications. Abstract Text:

Shin-ichi Kanemaru,Tatsuo Nakamura,Koichi Omori,Akhmar Magrufov,Masaru Yamashita,Yasuhiko Shimizu,Haruo Takahashi,Juichi Ito,

The objective of this study was to establish a method for regenerating mastoid air cells and their functions for clinical use in incurable otitis media. For this clinical study three patients (one male, two female) were randomly selected from patients with severe cholesteatoma about to undergo staged operations. Hydroxy-apatite in three-dimensional, honeycomb-like structures (3D-HA) were used as artificial pneumatic bones. This 3D-HA is made of calcium phosphate and has a high percentage of micropores (90%). Its surface is coated with collagen. At the first stage of tympanoplasty, collagen-coated 3D-HA was put into the opened mastoid cavity and fixed by fibrin glue. Recovery of mastoid aeration and regeneration of the pneumatic air cells of the mastoid cavity were estimated on CT scan images after the first operation. Aeration was recovered in all cases. The mastoid air cells were regenerated in two cases. In the failed case, subcutaneous connective tissues and granulations invaded into the spaces of the 3D-HA. This study demonstrated that mucosa would grow on the surface of a 3D-HA implant and could provide gas exchange functions in the newly opened mastoid cavity. This tissue engineering method may be a possible treatment for intractable otitis media.

Regeneration of mastoid air cells: clinical applications. Publishing Authors By Initials

S Kanemaru,T Nakamura,K Omori,A Magrufov,M Yamashita,Y Shimizu,H Takahashi,J Ito,

For similar diagnosis: prognosis: treatment outcome research abstracts see: diagnosis: prognosis: treatment outcome research

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Regeneration of mastoid air cells: clinical applications. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Acta oto-laryngologica. Supplementum

VOLUME:

Page Numbers: 80-4

Journal Abbreviation:

ISSN: 0365-5237

DAY: 13

MONTH: Mar

YEAR: 2004

Regeneration of mastoid air cells: clinical applications. Information

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LANGUAGE: eng

NlmUniqueID: 370355

Regeneration of mastoid air cells: clinical applications. Keywords Mesh Terms:

KEYWORDS: Treatment Outcome

MESH TERMS: physiology

Chemical & Substance for Abstract: Regeneration of mastoid air cells: clinical applications. Information

Substance Name: Durapatite

Registry Number: 1306-06-5

Grant and Affiliation Information for Regeneration of mastoid air cells: clinical applications.

AFFILIATION: Department of Otolaryngology--Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan. kanemaru@ent.kuhp.kyoto-u.ac.jp

Country: Norway

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MEDLINETA: Acta Otolaryngol Suppl

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